Industry Events Board (pharmaceutics and related)

This board records and monitors material events occurred in United States(US), Europe(EU), and Canada(CA) -- reported by companies in the industries including pharmaceuticals(n=646), biological products (diagnostic and non diagnostic)(n=184), commercial physical/biological research or service(n=16). For US, this board tracks status of interventional clinical trials submitted to ClinicalTrials.gov, FDA Human/Animal drugs submission, tentative approval, and marketing status, as well as CBER approved biological products. For EU, it tracks Europe Medicines Agency (EMA) regulated Human/Animal drugs marketing, and summary of opinion. For CA, it tracks Human/Animal drugs marketing and approval regulated by Canadian Food Inspection Agency (CFIA) and Health Canada.

This board provides powerful sorting strategies to help investors find, for example, companies with the most recent drug marketing in specific country/area, or with most approvals in specific year, or with research focus in specific disease condition(s). The information are presented together with Simple Moving Average (SMA) thumbnail chart and links to insider tradings and institutional holdings. For each company, there is also a standalone webpage describing the details of clinical trials and a list of drugs that are approved/marketed.

Sort Results

by US clinical trial count (largest first):

Year: Recruitment Status: Phase:

by US clinical trial focus of disease condition(s):

Status(es): Phase(s):

Show Other Sort/Display Options

by US FDA submission count (largest first):

Year: Type:

by US FDA submission time (latest first):

Type(s):

by US drug marketing count (largest first):

Year: Scope: Status:

by EU drug marketing count (largest first):

Year: Scope: Status:

by CA drug marketing count (largest first):

Year: Scope: Status:

by US drug marketing time (latest first):

Scope(s): Status(es):

by EU drug marketing time (latest first):

Scope(s): Status(es):

by CA drug marketing time (latest first):

Scope(s): Status(es):

Display Options

Force Include Symbol
(pharmaceutics and related company):
Historical Years: Clinical Trial Status(es): Clinical Trial Phase(s):
Thumbnail SMA: SMA Years:
Max Records Number:

Instructions

Only one sorting strategy will be applied for each query. When no checkbox is selected, default is "by US clinical trial count".

Count related sort: (e.g. by US clinical trial count; by US FDA submission count) orders results descendingly by the number of matched records.

Time related sort: (e.g. by US FDA submission time; by US drug marketing time) orders results by the most recent update time. For each option, when multiple categories are selected (e.g. both Phase 1 and Phase 2 are selected), the sorting will be based on the most recent update in either category, whichever contains the latest update.

US clinical trial focus of disease condition(s): select one or more disease conditions from the left box and move to the right box. The search results will be sorted based on relevence to condition(s) appearred in the right box.

Clinical trial recruitment statuses: simplified to 4 major categories according to the original statuses appearred in interventional studies on ClinicalTrails.gov.

Ongoing: Active, not recruiting; Enrolling by invitation; Recruiting; Not yet recruiting
Finished: Completed
Abnormal: Unknown status; Suspended
Aborted: Terminated; Withdrawn

Clinical trial phases: simplified to 5 major categories according to the original phases used by ClinicalTrails.gov

Phase 1: Early Phase 1; Phase 1
Phase 2: Phase 1|Phase 2; Phase 2
Phase 3: Phase 2|Phase 3; Phase 3
Phase 4: Phase 4
Phase NA: All other scenarios


US FDA submission types

Type 1: Type 1 - New Molecular Entity; Type 1 - New Molecular Entity and Type 4 - New Combination

Type 2: Type 2 - New Active Ingredient; Type 2 - New Active Ingredient and Type 3 - New Dosage Form; Type 2 New Active Ingredient and Type 4 New Combination

Type 3: Type 3 - New Dosage Form; Type 3 - New Dosage Form and Type 4 - New Combination

Others: All other scenarios


US, EU, CA drug marketing status

US drugs scope "Bioproduct" contains biological products that are approved by the Center for Biologics Evaluation and Research (CBER).

US drugs status "Tentative Approval": granted by the FDA if an abbreviated new drug application(ANDA) meets the substantive requirements for approval but cannot obtain final approval due to unexpired patents or exclusivities.

Europe drugs status "positive": summary of opinion published by European Medicines Agency (EMA) based on the CHMP's or CVMP's positive or negative recommendation. This summary is replaced by a full European public assessment reports once the European Commission has decided - taking the EMA opinion into consideration - whether to grant the marketing authorisation.

Drug products with same active ingredient but different forms or dosage strengthes are counted only once

Force include symbols

Add trading symbols for any pharmaceutics related company. The corresponding records will be forced to be displayed at the begining of the retrieved results. The force included records have lightgreen background.

Result Table Explained

Clinical trail count: the number of clinical trials started in corresponding year.
FDA submissions: the number of "ORIGINAL" (i.e. Supplementary not considered) FDA submissions in corresponding year.
latest update ≤ 7 days
latest update ≤ 30 days
latest update ≤ 90 days


Data last updated 2024-04-23 23:25:05 -0500 US CDT

US Clinical Trials and FDA Submissions

Symbol SMA (50w/20w/10w/5w / 50d/20d/10d/5d) Research Focus Year Clinical Trials Count US FDA submissions
Ongoing
Phase 1 Phase 2 Phase 3 Phase 4 Type 1 Type 2 Type 3 Others
AZN
(AstraZeneca PLC)
pharmaceuticals
Insider Trading
Institutional Holding
Phase 1:Ongoing:
          Neoplasms(16)
          Carcinoma, Non-Small-Cell Lung(8)
          Breast Neoplasms(6)
          Dyslipidemias(3)
          Lung Neoplasms(3)
          COVID-19(2)
          Liver Diseases(2)
          Crohn Disease(2)
          Small Cell Lung Carcinoma(2)
          Fatty Liver(2)
          Carcinoma, Renal Cell(2)
          (skip...)

Phase 1:Finished:
          Diabetes Mellitus, Type 2(58)
          Neoplasms(55)
          Diabetes Mellitus(25)
          Pulmonary Disease, Chronic Obstructive(23)
          Lung Diseases, Obstructive(22)
          Carcinoma, Non-Small-Cell Lung(15)
          Arthritis(14)
          Arthritis, Rheumatoid(13)
          Alzheimer Disease(13)
          Asthma(12)
          Breast Neoplasms(12)
          (skip...)

Phase 1:Aborted:
          Neoplasms(11)
          Diabetes Mellitus, Type 2(4)
          Pulmonary Disease, Chronic Obstructive(4)
          Leukemia, Myeloid, Acute(4)
          Leukemia, Myeloid(4)
          Lymphoma(4)
          Lung Diseases, Obstructive(3)
          Leukemia(3)
          Heart Failure(2)
          Breast Neoplasms(2)
          Diabetes Mellitus(2)
          (skip...)

Phase 2:Ongoing:
          Carcinoma, Non-Small-Cell Lung(16)
          Lung Neoplasms(15)
          Neoplasms(11)
          Lymphoma(6)
          Breast Neoplasms(6)
          Stomach Neoplasms(6)
          Adenocarcinoma(5)
          Fibrosis(4)
          Carcinoma(4)
          Carcinoma, Hepatocellular(3)
          Hypertension(3)
          (skip...)

Phase 2:Finished:
          Lung Diseases, Obstructive(32)
          Pulmonary Disease, Chronic Obstructive(31)
          Diabetes Mellitus(29)
          Breast Neoplasms(28)
          Diabetes Mellitus, Type 2(28)
          Lung Diseases(27)
          Asthma(25)
          Carcinoma, Non-Small-Cell Lung(14)
          Prostatic Neoplasms(14)
          Lung Neoplasms(13)
          (9)
          (skip...)

Phase 2:Abnormal:
          Kidney Neoplasms(1)
          Carcinoma, Renal Cell(1)
          Carcinoma(1)

Phase 2:Aborted:
          Arthritis, Rheumatoid(5)
          Arthritis(5)
          Carcinoma, Non-Small-Cell Lung(5)
          Lung Neoplasms(5)
          Pulmonary Disease, Chronic Obstructive(3)
          Lung Diseases(3)
          Depression(3)
          Depressive Disorder(3)
          Diabetes Mellitus, Type 2(3)
          Colorectal Neoplasms(3)
          Neoplasms(3)
          (skip...)

Phase 3:Ongoing:
          Carcinoma, Non-Small-Cell Lung(27)
          Lung Neoplasms(23)
          Breast Neoplasms(18)
          Carcinoma(13)
          Asthma(12)
          Pulmonary Disease, Chronic Obstructive(9)
          Lung Diseases, Obstructive(9)
          Lung Diseases(9)
          Carcinoma, Hepatocellular(6)
          Prostatic Neoplasms(5)
          Carcinoma, Ovarian Epithelial(5)
          (skip...)

Phase 3:Finished:
          Asthma(97)
          Diabetes Mellitus, Type 2(97)
          Diabetes Mellitus(88)
          Pulmonary Disease, Chronic Obstructive(44)
          Lung Diseases, Obstructive(44)
          Lung Diseases(37)
          Hypercholesterolemia(25)
          Depressive Disorder(23)
          Depression(23)
          Breast Neoplasms(18)
          Disease(18)
          (skip...)

Phase 3:Abnormal:
          Carcinoma, Non-Small-Cell Lung(2)
          Lung Neoplasms(2)
          Diabetes Mellitus, Type 2(1)
          Diabetes Mellitus(1)

Phase 3:Aborted:
          Diabetes Mellitus, Type 2(14)
          Schizophrenia(4)
          Diabetes Mellitus(4)
          Hyperkalemia(3)
          Alzheimer Disease(3)
          Asthma(3)
          Renal Insufficiency, Chronic(2)
          Crohn Disease(2)
          Anemia, Sickle Cell(2)
          Dementia(2)
          Breast Neoplasms(2)
          (skip...)

Phase 4:Ongoing:
          Asthma(3)
          Hyperkalemia(2)
          Diabetes Mellitus, Type 2(1)
          Pulmonary Eosinophilia(1)
          Prostatic Neoplasms(1)
          Renal Insufficiency, Chronic(1)
          Kidney Diseases(1)
          Carcinoma, Non-Small-Cell Lung(1)
          Heart Failure(1)

Phase 4:Finished:
          Diabetes Mellitus, Type 2(23)
          Diabetes Mellitus(22)
          Gastroesophageal Reflux(21)
          Asthma(17)
          Pulmonary Disease, Chronic Obstructive(15)
          Lung Diseases, Obstructive(13)
          Lung Diseases(11)
          Schizophrenia(9)
          Esophagitis, Peptic(7)
          Carcinoma, Non-Small-Cell Lung(6)
          Heartburn(6)
          (skip...)

Phase 4:Aborted:
          Diabetes Mellitus, Type 2(3)
          Diabetes Mellitus(3)
          Hypercholesterolemia(3)
          Bipolar Disorder(3)
          Prostatic Neoplasms(2)
          COVID-19(1)
          Hyperkalemia(1)
          Pneumonia(1)
          Pulmonary Disease, Chronic Obstructive(1)
          Lung Diseases, Obstructive(1)
          Lung Diseases(1)
          (skip...)

Phase Not Applicable:Ongoing:
          Asthma(1)

Phase Not Applicable:Finished:
          Asthma(4)
          Hyperlipidemias(1)
          Dyslipidemias(1)
          Hypertension(1)
          Infarction(1)
          Myocardial Infarction(1)
          Carcinoma, Non-Small-Cell Lung(1)
          Lung Neoplasms(1)
          Cardiovascular Diseases(1)
          Peripheral Vascular Diseases(1)
          Peripheral Arterial Disease(1)
          (skip...)

ALL 64 82 143 9 29 3 18 30
2024 9 6 8 1 - - - -
2023 17 24 33 - 2 - - 2
2022 10 14 23 4 1 - 1 1
MRK
(Merck & Company Inc.)
pharmaceuticals
Insider Trading
Institutional Holding
Phase 1:Ongoing:
          Neoplasms(8)
          Renal Insufficiency(3)
          Alzheimer Disease(3)
          Carcinoma, Renal Cell(3)
          Carcinoma(3)
          Prostatic Neoplasms(2)
          Hematologic Neoplasms(2)
          Kidney Failure, Chronic(2)
          (2)
          Lymphoma, B-Cell(2)
          Cognitive Dysfunction(2)
          (skip...)

Phase 1:Finished:
          Diabetes Mellitus, Type 2(39)
          Hepatitis C(32)
          Diabetes Mellitus(28)
          Neoplasms(27)
          Hepatitis(26)
          Renal Insufficiency(24)
          Hypertension(22)
          Hepatitis A(18)
          HIV Infections(15)
          Liver Failure(12)
          Hepatic Insufficiency(12)
          (skip...)

Phase 1:Aborted:
          Neoplasms(13)
          Leukemia, Myeloid(6)
          Leukemia(6)
          Hepatitis(5)
          Hepatitis C, Chronic(5)
          Hepatitis C(5)
          Hepatitis A(4)
          Renal Insufficiency(4)
          Precursor Cell Lymphoblastic Leukemia-Lymphoma(4)
          Leukemia, Myeloid, Acute(3)
          Leukemia, Myelogenous, Chronic, BCR-ABL Positive(3)
          (skip...)

Phase 2:Ongoing:
          Carcinoma(15)
          Neoplasms(11)
          Lymphoma(9)
          Carcinoma, Renal Cell(8)
          Carcinoma, Non-Small-Cell Lung(5)
          Melanoma(5)
          Hodgkin Disease(4)
          Lymphoma, B-Cell(4)
          Esophageal Neoplasms(3)
          Hypertension(3)
          Infections(3)
          (skip...)

Phase 2:Finished:
          Hepatitis(31)
          Hepatitis C(31)
          Hepatitis A(29)
          Hepatitis C, Chronic(24)
          Infections(18)
          Carcinoma(16)
          Carcinoma, Non-Small-Cell Lung(14)
          Diabetes Mellitus, Type 2(13)
          Breast Neoplasms(13)
          HIV Infections(13)
          Communicable Diseases(12)
          (skip...)

Phase 2:Abnormal:
          HIV Infections(4)

Phase 2:Aborted:
          Carcinoma, Non-Small-Cell Lung(9)
          Diabetes Mellitus, Type 2(8)
          Neoplasms(8)
          Diabetes Mellitus(7)
          (6)
          Hepatitis C(5)
          Hepatitis A(5)
          Lung Diseases(5)
          Hepatitis(4)
          Syndrome(4)
          Infections(4)
          (skip...)

Phase 3:Ongoing:
          Carcinoma, Non-Small-Cell Lung(22)
          Lung Neoplasms(22)
          Carcinoma(21)
          Carcinoma, Squamous Cell(7)
          Carcinoma, Renal Cell(7)
          Infections(6)
          Papillomavirus Infections(6)
          Adenocarcinoma(6)
          Melanoma(6)
          Hypertension(5)
          Familial Primary Pulmonary Hypertension(5)
          (skip...)

Phase 3:Finished:
          Diabetes Mellitus, Type 2(72)
          Diabetes Mellitus(71)
          Hepatitis(46)
          Hepatitis A(45)
          Hepatitis C(36)
          Hepatitis C, Chronic(30)
          Pneumococcal Infections(29)
          Infections(29)
          Communicable Diseases(23)
          Herpes Zoster(22)
          Papillomavirus Infections(20)
          (skip...)

Phase 3:Abnormal:
          Papillomavirus Infections(1)

Phase 3:Aborted:
          Diabetes Mellitus, Type 2(13)
          Hepatitis(10)
          Hepatitis A(10)
          Hepatitis C(9)
          Hepatitis C, Chronic(7)
          Dyslipidemias(6)
          Diabetes Mellitus(6)
          Hypercholesterolemia(5)
          Hepatitis, Chronic(3)
          Herpes Zoster(3)
          Osteoporosis(3)
          (skip...)

Phase 4:Ongoing:
          Squamous Cell Carcinoma of Head and Neck(1)
          Carcinoma, Squamous Cell(1)
          Carcinoma(1)
          Melanoma(1)
          Carcinoma, Non-Small-Cell Lung(1)

Phase 4:Finished:
          Sclerosis(10)
          Multiple Sclerosis(10)
          Diabetes Mellitus, Type 2(7)
          Diabetes Mellitus(7)
          Hepatitis(7)
          Infections(7)
          Hypertension(6)
          Hepatitis A(6)
          Vomiting(6)
          Nausea(6)
          Spondylitis(5)
          (skip...)

Phase 4:Aborted:
          Hepatitis(8)
          Hepatitis A(8)
          Hepatitis C(7)
          Hepatitis C, Chronic(6)
          Infertility(4)
          Psoriasis(3)
          Diabetes Mellitus, Type 2(2)
          Diabetes Mellitus(2)
          Spondylitis, Ankylosing(2)
          Spondylitis(2)
          Breast Neoplasms(2)
          (skip...)

Phase Not Applicable:Finished:
          HIV Infections(6)
          Osteoporosis(4)
          Diabetes Mellitus, Type 2(2)
          Diabetes Mellitus(2)
          Pulmonary Disease, Chronic Obstructive(1)
          Lung Diseases(1)
          Glucose Intolerance(1)
          Hyperglycemia(1)
          Insulin Resistance(1)
          Hypertension(1)
          Asthma(1)
          (skip...)

Phase Not Applicable:Aborted:
          Multiple Myeloma(1)

ALL 37 77 136 2 41 6 33 26
2024 5 4 8 - - - - -
2023 8 10 22 - - - - -
2022 8 13 17 - - - - -
NVS
(Novartis AG)
pharmaceuticals
Insider Trading
Institutional Holding
Phase 1:Ongoing:
          Carcinoma, Non-Small-Cell Lung(6)
          Melanoma(5)
          Colorectal Neoplasms(5)
          Glioblastoma(4)
          Carcinoma(4)
          Lymphoma, Non-Hodgkin(3)
          Lymphoma(3)
          Neoplasms, Plasma Cell(3)
          Multiple Myeloma(3)
          Leukemia(3)
          Carcinoma, Renal Cell(3)
          (skip...)

Phase 1:Finished:
          Neoplasms(51)
          Breast Neoplasms(26)
          Liver Diseases(23)
          Renal Insufficiency(17)
          Lymphoma(14)
          Multiple Myeloma(11)
          Leukemia(11)
          Neoplasms, Plasma Cell(10)
          Leukemia, Myeloid(10)
          Carcinoma, Non-Small-Cell Lung(9)
          Lung Neoplasms(9)
          (skip...)

Phase 1:Aborted:
          Neoplasms(11)
          Leukemia(7)
          Carcinoma, Non-Small-Cell Lung(6)
          Leukemia, Lymphoid(5)
          Lymphoma(4)
          Colorectal Neoplasms(4)
          Carcinoma(4)
          Lung Neoplasms(3)
          Renal Insufficiency(3)
          Neoplasm Metastasis(3)
          Prostatic Neoplasms(3)
          (skip...)

Phase 2:Ongoing:
          Leukemia(12)
          Leukemia, Myeloid(10)
          Breast Neoplasms(7)
          Leukemia, Myelogenous, Chronic, BCR-ABL Positive(7)
          Prostatic Neoplasms(6)
          Osteoarthritis(6)
          Osteoarthritis, Knee(5)
          Lung Neoplasms(5)
          Carcinoma, Non-Small-Cell Lung(5)
          Syndrome(5)
          Myelodysplastic Syndromes(4)
          (skip...)

Phase 2:Finished:
          Influenza, Human(42)
          Asthma(33)
          Breast Neoplasms(28)
          Leukemia(28)
          Syndrome(24)
          Hypertension(23)
          Meningococcal Infections(22)
          Carcinoma(21)
          Pulmonary Disease, Chronic Obstructive(18)
          Neoplasms(18)
          Leukemia, Myeloid(17)
          (skip...)

Phase 2:Aborted:
          Asthma(11)
          Breast Neoplasms(11)
          Carcinoma(10)
          Leukemia(10)
          Carcinoma, Non-Small-Cell Lung(9)
          Lung Neoplasms(8)
          Neoplasms(8)
          Syndrome(8)
          Leukemia, Myeloid(7)
          Hypertension(6)
          (5)
          (skip...)

Phase 3:Ongoing:
          Sclerosis(9)
          Syndrome(8)
          Multiple Sclerosis(8)
          Hypercholesterolemia(6)
          Leukemia(6)
          Urticaria(5)
          Cardiovascular Diseases(5)
          Breast Neoplasms(5)
          Leukemia, Myelogenous, Chronic, BCR-ABL Positive(5)
          Leukemia, Myeloid(5)
          Chronic Urticaria(4)
          (skip...)

Phase 3:Finished:
          Hypertension(105)
          Diabetes Mellitus, Type 2(65)
          Diabetes Mellitus(62)
          Pulmonary Disease, Chronic Obstructive(55)
          Lung Diseases, Obstructive(55)
          Influenza, Human(50)
          Lung Diseases(45)
          Meningococcal Infections(35)
          Breast Neoplasms(35)
          Psoriasis(30)
          Meningitis(28)
          (skip...)

Phase 3:Aborted:
          Carcinoma, Non-Small-Cell Lung(7)
          Leukemia(7)
          Uveitis(6)
          Breast Neoplasms(6)
          Syndrome(6)
          Pulmonary Disease, Chronic Obstructive(5)
          Macular Edema(5)
          Sclerosis(5)
          Multiple Sclerosis(5)
          Lung Neoplasms(5)
          Hepatitis(5)
          (skip...)

Phase 4:Ongoing:
          Sclerosis(6)
          Multiple Sclerosis(5)
          Breast Neoplasms(2)
          Multiple Sclerosis, Relapsing-Remitting(2)
          Carcinoma, Non-Small-Cell Lung(2)
          Polycythemia(2)
          Polycythemia Vera(2)
          Leukemia, Myeloid(2)
          Plaque, Atherosclerotic(1)
          Infarction(1)
          Myocardial Infarction(1)
          (skip...)

Phase 4:Finished:
          Hypertension(63)
          Diabetes Mellitus(27)
          Diabetes Mellitus, Type 2(25)
          Sclerosis(21)
          Multiple Sclerosis(20)
          Pulmonary Disease, Chronic Obstructive(18)
          Macular Degeneration(17)
          Lung Diseases, Obstructive(16)
          Neoplasm Metastasis(16)
          Alzheimer Disease(14)
          Prostatic Neoplasms(13)
          (skip...)

Phase 4:Aborted:
          Sclerosis(5)
          Multiple Sclerosis(5)
          Fibrosis(4)
          Hepatitis(4)
          Diabetes Mellitus(4)
          Hypertension(4)
          Breast Neoplasms(4)
          Multiple Sclerosis, Relapsing-Remitting(3)
          Asthma(3)
          Cystic Fibrosis(3)
          Infections(3)
          (skip...)

Phase Not Applicable:Finished:
          Refractive Errors(4)
          Presbyopia(2)
          Heart Failure(2)
          Psoriasis(1)
          Arthritis, Psoriatic(1)
          Arthritis(1)
          Cardiovascular Diseases(1)
          Hyperopia(1)
          Pulmonary Disease, Chronic Obstructive(1)
          Lung Diseases, Obstructive(1)
          Lung Diseases(1)
          (skip...)

Phase Not Applicable:Aborted:
          Astigmatism(1)
          Cataract(1)

ALL 42 92 104 26 73 5 45 56
2024 3 2 4 2 - - - -
2023 5 13 23 2 - - 1 2
2022 8 19 20 4 1 1 - 1
ABBV
(AbbVie Inc.)
pharmaceuticals
Insider Trading
Institutional Holding
Phase 1:Ongoing:
          Neoplasms(12)
          Lymphoma(5)
          Carcinoma, Non-Small-Cell Lung(5)
          Lymphoma, B-Cell(4)
          Neoplasms, Plasma Cell(4)
          Multiple Myeloma(4)
          Leukemia, Lymphocytic, Chronic, B-Cell(4)
          Leukemia, Lymphoid(4)
          Lymphoma, Non-Hodgkin(4)
          Leukemia(3)
          Hematologic Neoplasms(3)
          (skip...)

Phase 1:Finished:
          Neoplasms(26)
          Leukemia(8)
          Lymphoma(7)
          Lung Neoplasms(6)
          Lymphoma, Non-Hodgkin(5)
          Leukemia, Lymphocytic, Chronic, B-Cell(5)
          Ovarian Neoplasms(5)
          Leukemia, Myeloid, Acute(4)
          Parkinson Disease(4)
          Leukemia, Lymphoid(4)
          Arthritis, Rheumatoid(4)
          (skip...)

Phase 1:Aborted:
          Leukemia, Myeloid, Acute(6)
          Leukemia, Myeloid(6)
          Leukemia(5)
          Neoplasms, Plasma Cell(4)
          Multiple Myeloma(4)
          Lymphoma(4)
          Lymphoma, Non-Hodgkin(4)
          Colorectal Neoplasms(3)
          Carcinoma, Non-Small-Cell Lung(2)
          Lymphoma, B-Cell(2)
          Breast Neoplasms(2)
          (skip...)

Phase 2:Ongoing:
          Lymphoma(5)
          Leukemia, Lymphocytic, Chronic, B-Cell(3)
          Leukemia, Lymphoid(3)
          Leukemia(3)
          (2)
          Colitis, Ulcerative(2)
          Colitis(2)
          Alzheimer Disease(2)
          Choroidal Effusions(2)
          Wet Macular Degeneration(2)
          Macular Degeneration(2)
          (skip...)

Phase 2:Finished:
          Hepatitis C(21)
          Hepatitis C, Chronic(19)
          Hepatitis A(18)
          Hepatitis(17)
          Arthritis(15)
          Arthritis, Rheumatoid(12)
          Hepatitis, Chronic(10)
          Infections(10)
          Leukemia(8)
          Lung Neoplasms(8)
          Communicable Diseases(7)
          (skip...)

Phase 2:Aborted:
          Arthritis(3)
          Alzheimer Disease(3)
          Arthritis, Rheumatoid(2)
          Neoplasms, Plasma Cell(2)
          Multiple Myeloma(2)
          Supranuclear Palsy, Progressive(2)
          Lung Neoplasms(2)
          Disease(2)
          Syndrome(1)
          Sjogren\'s Syndrome(1)
          Crohn Disease(1)
          (skip...)

Phase 3:Ongoing:
          Migraine Disorders(11)
          Arthritis(8)
          Crohn Disease(6)
          Arthritis, Psoriatic(5)
          Leukemia, Myeloid, Acute(5)
          Leukemia, Myeloid(5)
          Leukemia(5)
          (5)
          Colitis, Ulcerative(5)
          Colitis(5)
          Eczema(4)
          (skip...)

Phase 3:Finished:
          Hepatitis C(52)
          Hepatitis A(52)
          Hepatitis(47)
          Hepatitis C, Chronic(45)
          Infections(31)
          Psoriasis(26)
          Hepatitis, Chronic(22)
          Communicable Diseases(19)
          Parkinson Disease(12)
          Arthritis(11)
          Virus Diseases(10)
          (skip...)

Phase 3:Aborted:
          Small Cell Lung Carcinoma(2)
          Lung Neoplasms(2)
          Hepatitis C, Chronic(2)
          Hepatitis C(2)
          Hepatitis A(2)
          Kidney Diseases(2)
          Eczema(1)
          Dermatitis(1)
          Dermatitis, Atopic(1)
          Schizophrenia(1)
          Glioblastoma(1)
          (skip...)

Phase 4:Ongoing:
          Psoriasis(2)
          Inflammatory Bowel Diseases(1)
          Intestinal Diseases(1)
          Facies(1)
          Glaucoma, Open-Angle(1)
          Glaucoma(1)
          Eczema(1)
          Dermatitis(1)
          Dermatitis, Atopic(1)
          Panuveitis(1)
          Uveitis(1)
          (skip...)

Phase 4:Finished:
          Arthritis(5)
          Arthritis, Rheumatoid(4)
          Fibrosis(2)
          Exocrine Pancreatic Insufficiency(2)
          Cystic Fibrosis(2)
          Hypogonadism(2)
          Psoriasis(2)
          HIV Infections(2)
          Facies(1)
          Migraine Disorders(1)
          Pancreatitis, Chronic(1)
          (skip...)

Phase 4:Aborted:
          Exocrine Pancreatic Insufficiency(2)
          Pancreatitis, Chronic(1)
          Pancreatitis(1)
          Cystic Fibrosis(1)
          Pancreatic Neoplasms(1)
          Spondylarthritis(1)

ALL 39 35 89 8 42 6 48 41
2024 5 - 5 3 - - - -
2023 10 9 24 2 - - - -
2022 7 6 13 2 - - 1 -
LLY
(Lilly Eli & Company)
pharmaceuticals
Insider Trading
Institutional Holding
Phase 1:Ongoing:
          Overweight(6)
          Neoplasms(6)
          Obesity(5)
          Diabetes Mellitus(5)
          Breast Neoplasms(5)
          Diabetes Mellitus, Type 2(4)
          Carcinoma, Non-Small-Cell Lung(3)
          Recurrence(2)
          Prostatic Neoplasms(2)
          Liver Failure(2)
          Hepatic Insufficiency(2)
          (skip...)

Phase 1:Finished:
          Diabetes Mellitus(67)
          Diabetes Mellitus, Type 2(58)
          Neoplasms(49)
          Diabetes Mellitus, Type 1(26)
          Neoplasm Metastasis(24)
          Depressive Disorder, Major(17)
          Depressive Disorder(17)
          Alzheimer Disease(12)
          Renal Insufficiency(10)
          Carcinoma, Non-Small-Cell Lung(10)
          Overweight(8)
          (skip...)

Phase 1:Aborted:
          Diabetes Mellitus(5)
          Neoplasms(5)
          Diabetes Mellitus, Type 1(3)
          Diabetes Mellitus, Type 2(3)
          Triple Negative Breast Neoplasms(2)
          Carcinoma, Non-Small-Cell Lung(2)
          Carcinoma, Renal Cell(2)
          Neoplasm Metastasis(2)
          Carcinoma(2)
          Leukemia(2)
          Psoriasis(1)
          (skip...)

Phase 2:Ongoing:
          Obesity(8)
          Overweight(6)
          Diabetes Mellitus, Type 2(3)
          Diabetes Mellitus(3)
          Neoplasms(3)
          Neuralgia(2)
          Psoriasis(2)
          Renal Insufficiency, Chronic(2)
          Kidney Diseases(2)
          Arthritis, Rheumatoid(2)
          Arthritis(2)
          (skip...)

Phase 2:Finished:
          Carcinoma, Non-Small-Cell Lung(65)
          Lung Neoplasms(62)
          Breast Neoplasms(38)
          Diabetes Mellitus(23)
          Neoplasms(20)
          Diabetes Mellitus, Type 2(19)
          Carcinoma(19)
          Colorectal Neoplasms(15)
          Alzheimer Disease(10)
          Ovarian Neoplasms(10)
          Arthritis, Rheumatoid(9)
          (skip...)

Phase 2:Aborted:
          Lung Neoplasms(13)
          Carcinoma, Non-Small-Cell Lung(8)
          Diabetes Mellitus, Type 2(5)
          Diabetes Mellitus(5)
          Small Cell Lung Carcinoma(4)
          Carcinoma(3)
          Arthritis, Rheumatoid(2)
          Arthritis(2)
          Alzheimer Disease(2)
          Headache(2)
          Migraine Disorders(2)
          (skip...)

Phase 3:Ongoing:
          Diabetes Mellitus(19)
          Diabetes Mellitus, Type 2(18)
          Obesity(14)
          Overweight(10)
          Breast Neoplasms(8)
          Eczema(7)
          Dermatitis(7)
          Dermatitis, Atopic(7)
          (7)
          Colitis, Ulcerative(6)
          Colitis(6)
          (skip...)

Phase 3:Finished:
          Diabetes Mellitus(80)
          Diabetes Mellitus, Type 2(59)
          Depressive Disorder(24)
          Attention Deficit Disorder with Hyperactivity(23)
          Hyperkinesis(22)
          Depressive Disorder, Major(21)
          Diabetes Mellitus, Type 1(20)
          Lung Neoplasms(19)
          Osteoporosis(18)
          Carcinoma, Non-Small-Cell Lung(18)
          Depression(17)
          (skip...)

Phase 3:Aborted:
          Lupus Erythematosus, Systemic(4)
          Arthritis, Rheumatoid(4)
          Arthritis(4)
          Alzheimer Disease(3)
          Hypercholesterolemia(2)
          Schizophrenia(2)
          (1)
          Colitis, Ulcerative(1)
          Colitis(1)
          Psoriasis(1)
          Eczema(1)
          (skip...)

Phase 4:Ongoing:
          Diabetes Mellitus, Type 2(3)
          Diabetes Mellitus(3)
          Arthritis(3)
          Arthritis, Rheumatoid(2)
          Psoriasis(1)
          Arthritis, Psoriatic(1)

Phase 4:Finished:
          Diabetes Mellitus, Type 2(25)
          Diabetes Mellitus(21)
          Depressive Disorder(21)
          Attention Deficit Disorder with Hyperactivity(19)
          Schizophrenia(16)
          Depression(16)
          Osteoporosis(16)
          Hyperkinesis(14)
          Depressive Disorder, Major(13)
          Erectile Dysfunction(12)
          Disease(11)
          (skip...)

Phase 4:Aborted:
          Breast Neoplasms(2)
          Diabetes Mellitus, Type 2(2)
          Diabetes Mellitus(2)
          Attention Deficit Disorder with Hyperactivity(2)
          Hyperkinesis(2)
          Myofascial Pain Syndromes(1)
          Fibromyalgia(1)
          Bipolar Disorder(1)
          Marijuana Abuse(1)
          Disease(1)

Phase Not Applicable:Ongoing:
          Diabetes Mellitus, Type 2(1)
          Diabetes Mellitus(1)

Phase Not Applicable:Finished:
          Diabetes Mellitus(5)
          Diabetes Mellitus, Type 1(4)
          Diabetes Mellitus, Type 2(1)
          Migraine Disorders(1)

ALL 55 32 81 6 37 4 17 48
2024 14 3 7 1 - - - -
2023 20 12 23 1 1 - - 1
2022 8 7 15 2 1 - - -
PFE
(Pfizer Inc.)
pharmaceuticals
Insider Trading
Institutional Holding
Phase 1:Ongoing:
          Multiple Myeloma(6)
          Neoplasms, Plasma Cell(5)
          Lymphoma(4)
          Breast Neoplasms(4)
          Neoplasms(3)
          Renal Insufficiency(2)
          Liver Diseases(2)
          Squamous Cell Carcinoma of Head and Neck(2)
          Carcinoma(2)
          Melanoma(2)
          Colorectal Neoplasms(1)
          (skip...)

Phase 1:Finished:
          Alzheimer Disease(38)
          Diabetes Mellitus, Type 2(37)
          Neoplasms(33)
          Diabetes Mellitus(26)
          Arthritis, Rheumatoid(18)
          Arthritis(18)
          Liver Diseases(17)
          Renal Insufficiency(16)
          Overweight(14)
          Schizophrenia(11)
          Carcinoma, Non-Small-Cell Lung(10)
          (skip...)

Phase 1:Abnormal:
          COVID-19(1)

Phase 1:Aborted:
          Neoplasms(22)
          Breast Neoplasms(10)
          Carcinoma, Non-Small-Cell Lung(6)
          Lung Neoplasms(5)
          Diabetes Mellitus, Type 2(5)
          Schizophrenia(4)
          Carcinoma, Renal Cell(3)
          Carcinoma(3)
          Hypertension(3)
          Hypercholesterolemia(3)
          Colorectal Neoplasms(3)
          (skip...)

Phase 2:Ongoing:
          Breast Neoplasms(8)
          Neoplasms, Plasma Cell(4)
          Multiple Myeloma(4)
          Carcinoma, Non-Small-Cell Lung(3)
          Lymphoma, Large B-Cell, Diffuse(2)
          Lymphoma, B-Cell(2)
          Lymphoma(2)
          (2)
          Colitis, Ulcerative(2)
          Colitis(2)
          Lung Neoplasms(2)
          (skip...)

Phase 2:Finished:
          Arthritis(25)
          Carcinoma, Non-Small-Cell Lung(25)
          Arthritis, Rheumatoid(24)
          Breast Neoplasms(21)
          Lung Neoplasms(18)
          Alzheimer Disease(16)
          Psoriasis(14)
          Carcinoma(14)
          Diabetes Mellitus, Type 2(13)
          Diabetes Mellitus(13)
          Carcinoma, Renal Cell(13)
          (skip...)

Phase 2:Aborted:
          Breast Neoplasms(15)
          Carcinoma, Non-Small-Cell Lung(9)
          Lung Neoplasms(9)
          Diabetes Mellitus(7)
          Neoplasms(7)
          Infections(6)
          Alzheimer Disease(6)
          Diabetes Mellitus, Type 2(6)
          Schizophrenia(5)
          Osteoarthritis(5)
          Neuralgia(5)
          (skip...)

Phase 3:Ongoing:
          Migraine Disorders(8)
          Anemia, Sickle Cell(8)
          Hemophilia A(7)
          Hemophilia B(6)
          Neoplasms, Plasma Cell(4)
          Multiple Myeloma(4)
          Breast Neoplasms(4)
          Vitiligo(3)
          (3)
          Eczema(3)
          Dermatitis(3)
          (skip...)

Phase 3:Finished:
          Depression(31)
          Infections(30)
          Arthritis(29)
          Depressive Disorder(29)
          Pneumococcal Infections(28)
          Communicable Diseases(26)
          Depressive Disorder, Major(25)
          Arthritis, Rheumatoid(19)
          Disease(16)
          (16)
          Pneumonia(14)
          (skip...)

Phase 3:Abnormal:
          COVID-19(1)

Phase 3:Aborted:
          Osteoarthritis(9)
          Infections(9)
          Alzheimer Disease(8)
          Hypertension(7)
          Diabetes Mellitus(7)
          Communicable Diseases(7)
          Hypertension, Pulmonary(5)
          Anxiety Disorders(5)
          Carcinoma(5)
          Carcinoma, Non-Small-Cell Lung(5)
          Hyperlipidemias(5)
          (skip...)

Phase 4:Ongoing:
          Migraine Disorders(4)
          Carcinoma, Non-Small-Cell Lung(2)
          Neoplasms, Plasma Cell(1)
          Multiple Myeloma(1)
          Leukemia, Lymphoid(1)
          Precursor Cell Lymphoblastic Leukemia-Lymphoma(1)
          Leukemia(1)
          Invasive Fungal Infections(1)
          Mycoses(1)
          Myocarditis(1)
          Photophobia(1)
          (skip...)

Phase 4:Finished:
          Arthritis(18)
          Arthritis, Rheumatoid(14)
          Infections(12)
          Communicable Diseases(10)
          Psoriasis(9)
          Hemophilia A(9)
          Renal Insufficiency(9)
          Spondylitis, Ankylosing(8)
          Spondylitis(8)
          Depressive Disorder(8)
          Depression(8)
          (skip...)

Phase 4:Aborted:
          Arthritis(4)
          Hemophilia A(4)
          Attention Deficit Disorder with Hyperactivity(3)
          Hyperkinesis(3)
          Arthritis, Rheumatoid(3)
          Wounds and Injuries(3)
          Brain Injuries(3)
          (2)
          Endocrine System Diseases(2)
          Dwarfism, Pituitary(2)
          Venous Thromboembolism(2)
          (skip...)

Phase Not Applicable:Finished:
          Meningitis(11)
          Meningococcal Infections(11)
          Meningitis, Cryptococcal(10)
          Infections(8)
          HIV Infections(7)
          Communicable Diseases(6)
          Acquired Immunodeficiency Syndrome(6)
          Mycobacterium avium-intracellulare Infection(4)
          Mycobacterium Infections(4)
          Candidiasis(4)
          Immunologic Deficiency Syndromes(3)
          (skip...)

Phase Not Applicable:Aborted:
          Disease Progression(1)
          Amyloidosis(1)
          Cardiomyopathies(1)
          Heart Failure(1)
          Alzheimer Disease(1)
          Diabetes Mellitus, Type 2(1)
          Diabetes Mellitus(1)
          Cystitis, Interstitial(1)
          Cystitis(1)

ALL 49 44 66 12 73 7 52 63
2024 11 1 1 - - - - -
2023 17 11 11 2 6 - - -
2022 9 11 18 7 1 - - -
SNY
(Sanofi SA)
pharmaceuticals
Insider Trading
Institutional Holding
Phase 1:Ongoing:
          Neoplasms(2)
          Autoimmune Diseases(1)
          Respiratory Syncytial Virus Infections(1)
          Communicable Diseases(1)
          Infections(1)
          Hemophilia A(1)
          Influenza, Human(1)
          Osteogenesis Imperfecta(1)
          Anemia, Hemolytic(1)
          Anemia, Hemolytic, Autoimmune(1)
          Neoplasms, Plasma Cell(1)
          (skip...)

Phase 1:Finished:
          Neoplasms(36)
          Diabetes Mellitus(27)
          Diabetes Mellitus, Type 1(19)
          Diabetes Mellitus, Type 2(17)
          Hypercholesterolemia(9)
          Leukemia(9)
          Multiple Sclerosis(8)
          Arthritis, Rheumatoid(7)
          Arthritis(7)
          Influenza, Human(7)
          Gaucher Disease(6)
          (skip...)

Phase 1:Aborted:
          Neoplasms(4)
          Neoplasm Metastasis(2)
          Lung Neoplasms(2)
          Leukemia, Myeloid, Acute(2)
          Leukemia, Myeloid(2)
          Leukemia(2)
          Smallpox(2)
          Coronavirus Infections(1)
          Herpes Genitalis(1)
          Herpes Simplex(1)
          Neoplasms, Plasma Cell(1)
          (skip...)

Phase 2:Ongoing:
          Neoplasms, Plasma Cell(5)
          Multiple Myeloma(5)
          Dermatitis(4)
          Dermatitis, Atopic(4)
          (4)
          Lung Neoplasms(4)
          Hidradenitis(3)
          Hidradenitis Suppurativa(3)
          Respiratory Syncytial Virus Infections(3)
          Asthma(3)
          Carcinoma, Non-Small-Cell Lung(3)
          (skip...)

Phase 2:Finished:
          Influenza, Human(39)
          Breast Neoplasms(19)
          (18)
          Severe Dengue(17)
          Hemorrhagic Fevers, Viral(17)
          Dengue(17)
          Meningococcal Infections(17)
          Meningitis(16)
          Orthomyxoviridae Infections(15)
          Lung Neoplasms(15)
          Carcinoma, Non-Small-Cell Lung(14)
          (skip...)

Phase 2:Abnormal:
          Melanoma(2)

Phase 2:Aborted:
          Leukemia(6)
          Lymphoma(6)
          Breast Neoplasms(5)
          Syndrome(5)
          Sclerosis(5)
          Malaria(4)
          Leukemia, Myeloid, Acute(4)
          Carcinoma, Non-Small-Cell Lung(4)
          Lymphoma, Non-Hodgkin(4)
          Leukemia, Lymphoid(3)
          Precursor Cell Lymphoblastic Leukemia-Lymphoma(3)
          (skip...)

Phase 3:Ongoing:
          Sclerosis(9)
          Multiple Sclerosis(9)
          Dermatitis(4)
          Dermatitis, Atopic(4)
          Pulmonary Disease, Chronic Obstructive(4)
          Lung Diseases, Obstructive(4)
          Lung Diseases(4)
          Multiple Sclerosis, Chronic Progressive(4)
          Hemophilia A(4)
          Neoplasms, Plasma Cell(4)
          Multiple Myeloma(4)
          (skip...)

Phase 3:Finished:
          Diabetes Mellitus(77)
          Diabetes Mellitus, Type 2(67)
          Diphtheria(45)
          Whooping Cough(42)
          Tetanus(39)
          Influenza, Human(29)
          Meningococcal Infections(25)
          Hepatitis B(24)
          Poliomyelitis(22)
          Hepatitis(19)
          Depressive Disorder(19)
          (skip...)

Phase 3:Abnormal:
          Influenza, Human(1)
          Colorectal Neoplasms(1)

Phase 3:Aborted:
          Diabetes Mellitus, Type 2(14)
          Diabetes Mellitus(10)
          Hypercholesterolemia(4)
          Influenza, Human(3)
          Dyslipidemias(3)
          Recurrence(3)
          Atrial Fibrillation(3)
          Breast Neoplasms(2)
          Giant Cell Arteritis(2)
          Polymyalgia Rheumatica(2)
          Polycystic Kidney, Autosomal Dominant(2)
          (skip...)

Phase 4:Ongoing:
          Dermatitis(2)
          Dermatitis, Atopic(2)
          Asthma(2)
          Glycogen Storage Disease Type II(2)
          Eosinophilic Esophagitis(1)
          Esophagitis(1)
          Fabry Disease(1)
          Meningococcal Infections(1)
          Diabetes Mellitus, Type 1(1)
          Diabetes Mellitus(1)
          Rhinitis, Allergic(1)
          (skip...)

Phase 4:Finished:
          Diabetes Mellitus, Type 2(65)
          Diabetes Mellitus(58)
          Influenza, Human(33)
          Diphtheria(20)
          Hypertension(18)
          Whooping Cough(17)
          Tetanus(16)
          Diabetes Mellitus, Type 1(12)
          Rhinitis, Allergic(10)
          Rhinitis(10)
          Tetany(10)
          (skip...)

Phase 4:Aborted:
          Diabetes Mellitus, Type 2(7)
          Diabetes Mellitus(7)
          Atrial Fibrillation(3)
          Glycogen Storage Disease Type II(3)
          Fabry Disease(3)
          Pneumonia(3)
          Glycogen Storage Disease(2)
          Osteoporosis(2)
          Bronchitis, Chronic(2)
          Bronchitis(2)
          Infections(2)
          (skip...)

Phase Not Applicable:Ongoing:
          Rare Diseases(1)
          Gaucher Disease(1)
          Diabetes Mellitus, Type 2(1)
          Diabetes Mellitus(1)

Phase Not Applicable:Finished:
          Lipidoses(1)
          Niemann-Pick Disease, Type C(1)
          Niemann-Pick Diseases(1)
          Niemann-Pick Disease, Type A(1)
          Hepatitis(1)
          Hepatitis B(1)
          Diabetes Mellitus(1)
          Osteoarthritis, Hip(1)
          Osteoarthritis(1)
          Alopecia Areata(1)
          Alopecia(1)
          (skip...)

Phase Not Applicable:Aborted:
          Tissue Adhesions(2)
          Sinusitis(1)

ALL 11 74 58 12 47 2 30 48
2024 3 5 10 - - - - -
2023 2 20 9 6 - - - -
2022 1 14 8 1 - - - -
BMY
(Bristol-Myers Squibb Company)
pharmaceuticals
Insider Trading
Institutional Holding
Phase 1:Ongoing:
          Neoplasms(3)
          Neoplasms, Plasma Cell(2)
          Multiple Myeloma(2)
          Lymphoma, Non-Hodgkin(2)
          Lymphoma(2)
          Liver Diseases(1)
          Dermatitis(1)
          Dermatitis, Atopic(1)
          Sclerosis(1)
          Multiple Sclerosis(1)
          Prostatic Neoplasms(1)
          (skip...)

Phase 1:Finished:
          Hepatitis C(20)
          Neoplasms(19)
          HIV Infections(17)
          Arthritis(16)
          Thrombosis(15)
          Arthritis, Rheumatoid(14)
          Alzheimer Disease(11)
          Melanoma(11)
          Psoriasis(9)
          Heart Failure(8)
          Carcinoma(8)
          (skip...)

Phase 1:Abnormal:
          Glioblastoma(1)

Phase 1:Aborted:
          Leukemia(5)
          Neoplasms(4)
          Melanoma(3)
          Leukemia, Lymphocytic, Chronic, B-Cell(3)
          Leukemia, Lymphoid(3)
          Lymphoma(3)
          Leukemia, Myelogenous, Chronic, BCR-ABL Positive(3)
          Leukemia, Myeloid(3)
          Liver Diseases(2)
          Hypercholesterolemia(2)
          Hepatitis C(2)
          (skip...)

Phase 2:Ongoing:
          Neoplasms(7)
          Carcinoma(5)
          Carcinoma, Non-Small-Cell Lung(4)
          Lung Neoplasms(4)
          Multiple Myeloma(4)
          Lupus Erythematosus, Systemic(3)
          Melanoma(3)
          Colorectal Neoplasms(3)
          Carcinoma, Hepatocellular(3)
          Neoplasms, Plasma Cell(3)
          Lymphoma(3)
          (skip...)

Phase 2:Finished:
          Hepatitis(30)
          Hepatitis C(24)
          Hepatitis A(18)
          Melanoma(16)
          Leukemia(15)
          Carcinoma, Non-Small-Cell Lung(14)
          Breast Neoplasms(13)
          Arthritis(12)
          Lung Neoplasms(12)
          Leukemia, Myelogenous, Chronic, BCR-ABL Positive(12)
          Leukemia, Myeloid(12)
          (skip...)

Phase 2:Abnormal:
          Ketosis(1)
          Sclerosis(1)
          Multiple Sclerosis, Chronic Progressive(1)
          Multiple Sclerosis(1)
          Central Nervous System Neoplasms(1)
          Nervous System Neoplasms(1)
          Glioblastoma(1)

Phase 2:Aborted:
          Carcinoma, Non-Small-Cell Lung(7)
          Lung Neoplasms(7)
          Hepatitis(6)
          Hepatitis C(6)
          Hepatitis A(5)
          Melanoma(5)
          Hepatitis C, Chronic(4)
          Leukemia(4)
          Carcinoma(3)
          Neoplasms(3)
          Breast Neoplasms(3)
          (skip...)

Phase 3:Ongoing:
          Carcinoma, Non-Small-Cell Lung(6)
          Carcinoma(6)
          Melanoma(6)
          Hypertrophy(5)
          Cardiomyopathy, Hypertrophic(5)
          Cardiomyopathies(5)
          Lung Neoplasms(5)
          Syndrome(4)
          Carcinoma, Renal Cell(4)
          Neoplasms, Plasma Cell(3)
          Multiple Myeloma(3)
          (skip...)

Phase 3:Finished:
          Hepatitis(35)
          Hepatitis C(24)
          Arthritis(24)
          Hepatitis A(24)
          Arthritis, Rheumatoid(22)
          HIV Infections(17)
          Melanoma(14)
          Hepatitis B(12)
          Lung Neoplasms(11)
          Hepatitis B, Chronic(10)
          Carcinoma(8)
          (skip...)

Phase 3:Aborted:
          Hepatitis C(3)
          Hepatitis(3)
          Leukemia(3)
          Carcinoma, Non-Small-Cell Lung(2)
          Lung Neoplasms(2)
          Hepatitis A(2)
          Leukemia, Myelogenous, Chronic, BCR-ABL Positive(2)
          Leukemia, Lymphoid(2)
          Leukemia, Lymphocytic, Chronic, B-Cell(1)
          Lymphoma(1)
          Liver Neoplasms(1)
          (skip...)

Phase 4:Ongoing:
          Psoriasis(3)
          Hypertrophy(1)
          Cardiomyopathy, Hypertrophic(1)
          Cardiomyopathies(1)
          beta-Thalassemia(1)
          Thalassemia(1)
          Myelodysplastic Syndromes(1)
          Anemia(1)
          Preleukemia(1)
          (1)
          Colitis, Ulcerative(1)
          (skip...)

Phase 4:Finished:
          HIV Infections(4)
          Atrial Fibrillation(3)
          Hepatitis(3)
          Hepatitis B, Chronic(3)
          Hepatitis B(3)
          Syndrome(3)
          Diabetes Mellitus, Type 2(3)
          Kidney Neoplasms(2)
          Lung Neoplasms(2)
          Carcinoma, Renal Cell(2)
          Arthritis, Rheumatoid(2)
          (skip...)

Phase 4:Aborted:
          Hepatitis(1)
          Hepatitis B, Chronic(1)
          Hepatitis B(1)
          Schizophrenia(1)
          Syndrome(1)
          Metabolic Syndrome(1)
          HIV Infections(1)

Phase Not Applicable:Ongoing:
          Parkinson Disease(2)
          Critical Illness(1)
          Sclerosis(1)
          Tuberous Sclerosis(1)
          Atrial Flutter(1)
          Atrial Fibrillation(1)
          Parkinsonian Disorders(1)
          Lower Urinary Tract Symptoms(1)
          Urinary Bladder, Underactive(1)
          Hypokinesia(1)

Phase Not Applicable:Finished:
          HIV Infections(11)
          Infections(8)
          Acquired Immunodeficiency Syndrome(8)
          Communicable Diseases(5)
          Obesity(4)
          Candidiasis(3)
          Lung Neoplasms(2)
          Pediatric Obesity(2)
          Diabetes Mellitus(2)
          Candidiasis, Oral(2)
          AIDS-Related Complex(2)
          (skip...)

Phase Not Applicable:Abnormal:
          Depressive Disorder, Treatment-Resistant(1)
          Depressive Disorder(1)
          Depression(1)

Phase Not Applicable:Aborted:
          Pain, Postoperative(1)
          Surgical Wound(1)
          Surgical Wound Infection(1)
          Wound Infection(1)
          Choledocholithiasis(1)

ALL 27 55 56 8 36 1 18 36
2024 3 2 2 - - - - -
2023 14 7 8 5 1 - - -
2022 3 13 10 2 3 - - 1
NVO
(Novo Nordisk A S)
pharmaceuticals
Insider Trading
Institutional Holding
Phase 1:Ongoing:
          Obesity(4)
          Liver Diseases(4)
          Diabetes Mellitus, Type 2(3)
          Overweight(2)
          Diabetes Mellitus(2)
          Non-alcoholic Fatty Liver Disease(1)
          Fatty Liver(1)
          Neoplasms(1)
          Dyslipidemias(1)
          Inflammation(1)
          Renal Insufficiency, Chronic(1)
          (skip...)

Phase 1:Finished:
          Diabetes Mellitus(148)
          Diabetes Mellitus, Type 2(107)
          Diabetes Mellitus, Type 1(69)
          Blood Coagulation Disorders(31)
          Hemostatic Disorders(31)
          Overweight(29)
          Hemophilia A(25)
          Obesity(21)
          Nutrition Disorders(19)
          Hemophilia B(14)
          Inflammation(7)
          (skip...)

Phase 1:Aborted:
          Overweight(4)
          Inflammation(3)
          Nutrition Disorders(3)
          Blood Coagulation Disorders(2)
          Hemophilia A(2)
          Hemostatic Disorders(2)
          Obesity(2)
          Lupus Erythematosus, Systemic(2)
          Renal Insufficiency, Chronic(1)
          Kidney Diseases(1)
          Prostatic Neoplasms(1)
          (skip...)

Phase 2:Ongoing:
          Diabetes Mellitus, Type 2(2)
          Obesity(2)
          Diabetes Mellitus(2)
          Amyloidosis(2)
          Cardiomyopathies(2)
          Hyperoxaluria, Primary(2)
          Overweight(1)
          Renal Insufficiency, Chronic(1)
          Kidney Diseases(1)
          Anemia, Sickle Cell(1)
          Non-alcoholic Fatty Liver Disease(1)
          (skip...)

Phase 2:Finished:
          Diabetes Mellitus(33)
          Diabetes Mellitus, Type 2(29)
          Blood Coagulation Disorders(19)
          Hemostatic Disorders(19)
          Hemorrhage(9)
          Hemophilia A(7)
          Inflammation(6)
          Diabetes Mellitus, Type 1(6)
          Hemophilia B(5)
          Overweight(4)
          Obesity(4)
          (skip...)

Phase 2:Aborted:
          Inflammation(4)
          Arthritis, Rheumatoid(3)
          Arthritis(3)
          Hemorrhage(2)
          Blood Coagulation Disorders(2)
          Hemostatic Disorders(2)
          (1)
          Colitis, Ulcerative(1)
          Colitis(1)
          Diabetes Mellitus, Type 1(1)
          Diabetes Mellitus(1)
          (skip...)

Phase 3:Ongoing:
          Diabetes Mellitus, Type 2(17)
          Diabetes Mellitus(17)
          Obesity(12)
          Hemophilia A(8)
          Overweight(6)
          Kidney Diseases(4)
          Inflammation(3)
          Alzheimer Disease(3)
          Hemophilia B(3)
          Renal Insufficiency, Chronic(3)
          Heart Failure(2)
          (skip...)

Phase 3:Finished:
          Diabetes Mellitus(187)
          Diabetes Mellitus, Type 2(146)
          Diabetes Mellitus, Type 1(49)
          Blood Coagulation Disorders(22)
          Hemostatic Disorders(22)
          Obesity(20)
          Hemophilia A(17)
          Overweight(16)
          Dwarfism, Pituitary(12)
          Nutrition Disorders(10)
          Hemorrhage(10)
          (skip...)

Phase 3:Aborted:
          Diabetes Mellitus(15)
          Diabetes Mellitus, Type 2(14)
          Diabetes Mellitus, Type 1(3)
          Hemorrhage(2)
          Blood Coagulation Disorders(2)
          Hemostatic Disorders(2)
          Hemophilia A(1)
          Urinary Tract Infections(1)
          Communicable Diseases(1)
          Infections(1)
          Asthma(1)
          (skip...)

Phase 4:Ongoing:
          Obesity(1)
          Diabetes Mellitus, Type 2(1)
          Diabetes Mellitus(1)

Phase 4:Finished:
          Diabetes Mellitus(76)
          Diabetes Mellitus, Type 2(70)
          Diabetes Mellitus, Type 1(11)
          Blood Coagulation Disorders(4)
          Hemophilia A(4)
          Hemostatic Disorders(4)
          Genetic Diseases, Inborn(3)
          Turner Syndrome(3)
          Hemophilia B(3)
          Fetal Growth Retardation(2)
          Syndrome(2)
          (skip...)

Phase 4:Aborted:
          Diabetes Mellitus(4)
          Diabetes Mellitus, Type 2(3)
          Endocrine System Diseases(1)
          Dwarfism, Pituitary(1)
          Diabetes Mellitus, Type 1(1)

Phase Not Applicable:Finished:
          Diabetes Mellitus, Type 1(1)
          Diabetes Mellitus(1)

ALL 24 12 48 2 8 - 6 15
2024 9 3 5 - - - - -
2023 10 1 14 - 1 - - -
2022 5 2 12 1 - - - -
TAK
(Takeda Pharmaceutical Company Limited)
pharmaceuticals
Insider Trading
Institutional Holding
Phase 1:Ongoing:
          Neoplasms(3)
          Liver Diseases(2)
          Neoplasms, Plasma Cell(2)
          Multiple Myeloma(2)
          Carcinoma, Non-Small-Cell Lung(2)
          Lupus Nephritis(1)
          Nephritis(1)
          Renal Insufficiency(1)
          Glomerulonephritis(1)
          Kidney Diseases(1)
          Triple Negative Breast Neoplasms(1)
          (skip...)

Phase 1:Finished:
          Gastroesophageal Reflux(6)
          Liver Diseases(5)
          Diabetes Mellitus(4)
          Esophagitis, Peptic(4)
          Diabetes Mellitus, Type 2(3)
          Neoplasms(3)
          Narcolepsy(2)
          Epilepsy(2)
          Renal Insufficiency(2)
          Esophagitis(2)
          Schizophrenia(2)
          (skip...)

Phase 1:Aborted:
          Neoplasms, Plasma Cell(2)
          Multiple Myeloma(2)
          Cognitive Dysfunction(2)
          Schizophrenia(2)
          Coronavirus Infections(1)
          Alzheimer Disease(1)
          Gastroesophageal Reflux(1)
          Lupus Nephritis(1)
          Nephritis(1)
          Attention Deficit Disorder with Hyperactivity(1)
          Hyperkinesis(1)
          (skip...)

Phase 2:Ongoing:
          Leukemia(4)
          (3)
          Lymphoma(3)
          Multiple Myeloma(3)
          Leukemia, Myeloid(3)
          Carcinoma, Squamous Cell(2)
          Neoplasms, Squamous Cell(2)
          Neoplasm Metastasis(2)
          Celiac Disease(2)
          Neoplasms(2)
          Leukemia, Myeloid, Acute(2)
          (skip...)

Phase 2:Finished:
          Diabetes Mellitus(11)
          Diabetes Mellitus, Type 2(7)
          Dengue(6)
          Hypertension(5)
          Renal Insufficiency(5)
          (5)
          Arthritis(4)
          Sleep Initiation and Maintenance Disorders(4)
          Carcinoma(3)
          Gastroesophageal Reflux(3)
          Arthritis, Rheumatoid(3)
          (skip...)

Phase 2:Aborted:
          Narcolepsy(2)
          Lymphoma, Non-Hodgkin(2)
          Lymphoma(2)
          Neoplasms(2)
          Neoplasms, Plasma Cell(2)
          Multiple Myeloma(2)
          Crohn Disease(2)
          Recurrence(2)
          Arthritis, Rheumatoid(2)
          Arthritis(2)
          Diabetes Mellitus(2)
          (skip...)

Phase 3:Ongoing:
          Crohn Disease(9)
          (6)
          Colitis, Ulcerative(6)
          Colitis(6)
          Syndrome(4)
          Immunologic Deficiency Syndromes(4)
          Primary Immunodeficiency Diseases(4)
          Psoriasis(3)
          Alpha 1-Antitrypsin Deficiency(3)
          Liver Diseases(3)
          Dengue(3)
          (skip...)

Phase 3:Finished:
          Diabetes Mellitus(39)
          Diabetes Mellitus, Type 2(24)
          (23)
          Hypertension(22)
          Essential Hypertension(17)
          Esophagitis, Peptic(15)
          Gastroesophageal Reflux(15)
          Depressive Disorder, Major(13)
          Depression(13)
          Depressive Disorder(13)
          Disease(12)
          (skip...)

Phase 3:Aborted:
          Diabetes Mellitus(15)
          Diabetes Mellitus, Type 2(12)
          Hypercholesterolemia(4)
          Bipolar Disorder(3)
          Cognitive Dysfunction(2)
          Alzheimer Disease(2)
          Hypertension(2)
          Heart Failure(2)
          Constipation(1)
          Cholangitis, Sclerosing(1)
          Cholangitis(1)
          (skip...)

Phase 4:Ongoing:
          Crohn Disease(3)
          Mucopolysaccharidosis II(3)
          Syndrome(2)
          Mucopolysaccharidoses(2)
          Lymphoma(2)
          Surgical Wound Infection(1)
          Communicable Diseases(1)
          Infections(1)
          (1)
          Colitis, Ulcerative(1)
          Colitis(1)
          (skip...)

Phase 4:Finished:
          Diabetes Mellitus(13)
          Diabetes Mellitus, Type 2(7)
          Gastroesophageal Reflux(6)
          Esophagitis, Peptic(5)
          Crohn Disease(4)
          Hypertension(4)
          Sleep Initiation and Maintenance Disorders(4)
          (3)
          Colitis, Ulcerative(3)
          Colitis(3)
          Depressive Disorder, Major(3)
          (skip...)

Phase 4:Aborted:
          (2)
          Colitis, Ulcerative(2)
          Colitis(2)
          Crohn Disease(2)
          Emphysema(1)
          Pulmonary Disease, Chronic Obstructive(1)
          Lung Diseases, Obstructive(1)
          Lung Diseases(1)
          Alpha 1-Antitrypsin Deficiency(1)
          Neoplasms, Plasma Cell(1)
          Multiple Myeloma(1)
          (skip...)

Phase Not Applicable:Ongoing:
          Hemophilia A(1)

Phase Not Applicable:Finished:
          Celiac Disease(1)

ALL 16 30 43 12 23 1 13 8
2024 4 2 2 1 - - - -
2023 5 5 12 2 1 - - 1
2022 1 4 8 3 - - - -
AMGN
(Amgen Inc.)
biological products (diagnostic and non diagnostic)
Insider Trading
Institutional Holding
Phase 1:Ongoing:
          Lung Neoplasms(4)
          Dermatitis(3)
          Neoplasms(3)
          Prostatic Neoplasms(3)
          Small Cell Lung Carcinoma(3)
          Obesity(2)
          Carcinoma, Non-Small-Cell Lung(2)
          Leukemia(2)
          Pancreatic Neoplasms(1)
          Overweight(1)
          Thoracic Neoplasms(1)
          (skip...)

Phase 1:Finished:
          Neoplasms(18)
          Lupus Erythematosus, Systemic(10)
          Multiple Myeloma(7)
          Migraine Disorders(6)
          Renal Insufficiency(6)
          Kidney Diseases(6)
          Bone Diseases, Metabolic(6)
          Neoplasms, Plasma Cell(6)
          Lymphoma(6)
          Vasculitis(5)
          Liver Diseases(5)
          (skip...)

Phase 1:Abnormal:
          Small Cell Lung Carcinoma(1)
          Lung Neoplasms(1)

Phase 1:Aborted:
          Leukemia, Myeloid, Acute(5)
          Leukemia, Myeloid(5)
          Leukemia(5)
          Multiple Myeloma(5)
          Neoplasms, Plasma Cell(4)
          Diabetes Mellitus, Type 2(3)
          Diabetes Mellitus(3)
          Neoplasms(3)
          Carcinoma, Non-Small-Cell Lung(3)
          Adenocarcinoma(2)
          Asthma(2)
          (skip...)

Phase 2:Ongoing:
          Neoplasms(4)
          (2)
          Colitis, Ulcerative(2)
          Colitis(2)
          Carcinoma, Non-Small-Cell Lung(2)
          Leukemia, Lymphoid(2)
          Precursor Cell Lymphoblastic Leukemia-Lymphoma(2)
          Leukemia(2)
          Asthma(1)
          Overweight(1)
          Diabetes Mellitus, Type 2(1)
          (skip...)

Phase 2:Finished:
          Colorectal Neoplasms(16)
          Lung Neoplasms(13)
          Anemia(13)
          Neoplasms(13)
          Arthritis(12)
          Carcinoma(11)
          Lymphoma(11)
          Multiple Myeloma(11)
          Breast Neoplasms(9)
          Neoplasm Metastasis(9)
          Carcinoma, Non-Small-Cell Lung(9)
          (skip...)

Phase 2:Abnormal:
          Lung Neoplasms(1)
          Prostatic Neoplasms(1)
          Lymphoma, Non-Hodgkin(1)
          Lymphoma(1)
          Ureteral Neoplasms(1)
          Kidney Neoplasms(1)
          Carcinoma, Transitional Cell(1)
          Urinary Bladder Neoplasms(1)

Phase 2:Aborted:
          Multiple Myeloma(4)
          Arthritis, Rheumatoid(4)
          Arthritis(4)
          Neoplasms, Plasma Cell(3)
          Adenocarcinoma(3)
          Anemia(3)
          Schizophrenia(2)
          Crohn Disease(2)
          Neoplasms(2)
          Lupus Erythematosus, Systemic(2)
          Lupus Nephritis(1)
          (skip...)

Phase 3:Ongoing:
          Eczema(8)
          Dermatitis(8)
          Dermatitis, Atopic(8)
          Lung Neoplasms(6)
          Psoriasis(5)
          Carcinoma, Non-Small-Cell Lung(4)
          Small Cell Lung Carcinoma(3)
          Colorectal Neoplasms(3)
          Melanoma(2)
          Esophageal Neoplasms(2)
          Stomach Neoplasms(2)
          (skip...)

Phase 3:Finished:
          Kidney Diseases(26)
          Arthritis(22)
          Renal Insufficiency, Chronic(22)
          Osteoporosis(21)
          Psoriasis(21)
          Neoplasm Metastasis(18)
          Hyperparathyroidism(16)
          Arthritis, Rheumatoid(14)
          Hypercholesterolemia(13)
          Anemia(13)
          Hyperparathyroidism, Secondary(13)
          (skip...)

Phase 3:Aborted:
          Renal Insufficiency, Chronic(5)
          Kidney Diseases(5)
          Anemia(4)
          Carcinoma, Non-Small-Cell Lung(3)
          Lung Neoplasms(3)
          Dyslipidemias(2)
          Osteogenesis Imperfecta(2)
          Stomach Neoplasms(2)
          Fallopian Tube Neoplasms(2)
          Carcinoma, Ovarian Epithelial(2)
          Ovarian Neoplasms(2)
          (skip...)

Phase 4:Ongoing:
          Osteoporosis(2)
          Osteoporosis, Postmenopausal(1)
          Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis(1)
          Vasculitis(1)
          Infarction(1)
          Myocardial Infarction(1)
          Cardiovascular Diseases(1)
          Graves Ophthalmopathy(1)
          Eye Diseases(1)
          Giant Cell Tumor of Bone(1)
          Bone Neoplasms(1)
          (skip...)

Phase 4:Finished:
          Arthritis(14)
          Kidney Diseases(11)
          Arthritis, Rheumatoid(10)
          Psoriasis(9)
          Renal Insufficiency, Chronic(8)
          Hyperparathyroidism(6)
          Migraine Disorders(5)
          Hyperparathyroidism, Secondary(5)
          Renal Insufficiency(5)
          Kidney Failure, Chronic(5)
          Anemia(5)
          (skip...)

Phase 4:Aborted:
          Arthritis, Rheumatoid(2)
          Arthritis(2)
          Migraine Disorders(1)
          Bone Diseases(1)
          Anemia(1)
          Psoriasis(1)

Phase Not Applicable:Finished:
          Atherosclerosis(1)
          Cardiovascular Diseases(1)
          Syndrome(1)
          Thrombocytopenia(1)
          Myelodysplastic Syndromes(1)
          Preleukemia(1)
          Anemia(1)
          Heart Failure(1)
          HIV Infections(1)
          AIDS-Related Complex(1)
          Mycobacterium avium-intracellulare Infection(1)
          (skip...)

Phase Not Applicable:Aborted:
          Heart Failure(1)

ALL 21 15 41 8 16 1 1 6
2024 5 1 5 1 - - - -
2023 3 3 13 2 - - - 2
2022 5 2 6 1 - - - -
REGN
(Regeneron Pharmaceuticals Inc.)
pharmaceuticals
Insider Trading
Institutional Holding
Phase 1:Ongoing:
          Neoplasms(4)
          Non-alcoholic Fatty Liver Disease(2)
          Fatty Liver(2)
          Liver Diseases(2)
          Lymphoma(2)
          Food Hypersensitivity(1)
          Hypersensitivity(1)
          Sclerosis(1)
          Amyotrophic Lateral Sclerosis(1)
          Motor Neuron Disease(1)
          Aggression(1)
          (skip...)

Phase 1:Finished:
          Arthritis(5)
          Dermatitis(4)
          Dermatitis, Atopic(4)
          Arthritis, Rheumatoid(4)
          Macular Degeneration(4)
          Lymphoma(4)
          COVID-19(3)
          Melanoma(3)
          Neoplasms(3)
          Asthma(2)
          Eczema(2)
          (skip...)

Phase 1:Aborted:
          Neoplasms(2)
          COVID-19(1)
          Carcinoma, Non-Small-Cell Lung(1)
          Lung Neoplasms(1)
          Diabetes Mellitus, Type 2(1)
          Diabetes Mellitus(1)

Phase 2:Ongoing:
          Neoplasms, Plasma Cell(5)
          Multiple Myeloma(5)
          Carcinoma, Non-Small-Cell Lung(3)
          Lung Neoplasms(3)
          Smoldering Multiple Myeloma(2)
          Venous Thromboembolism(2)
          Thromboembolism(2)
          Heart Failure(2)
          Lipodystrophy(2)
          Prostatic Neoplasms(2)
          Carcinoma(2)
          (skip...)

Phase 2:Finished:
          Eczema(6)
          Dermatitis(6)
          Dermatitis, Atopic(6)
          Hypercholesterolemia(5)
          Macular Degeneration(4)
          Hemoglobinuria, Paroxysmal(3)
          Hemoglobinuria(3)
          Carcinoma(3)
          Hyperlipoproteinemia Type II(3)
          COVID-19(2)
          Peanut Hypersensitivity(2)
          (skip...)

Phase 2:Abnormal:
          Carcinoma, Basal Cell(1)
          Neoplasm Metastasis(1)
          Triple Negative Breast Neoplasms(1)
          Carcinoma, Squamous Cell(1)
          Carcinoma(1)
          Carcinoma, Merkel Cell(1)

Phase 2:Aborted:
          Eczema(3)
          Dermatitis(3)
          Dermatitis, Atopic(3)
          Osteoarthritis, Knee(3)
          Osteoarthritis(3)
          COVID-19(2)
          Pancreatitis(2)
          Carcinoma, Non-Small-Cell Lung(2)
          Hypertriglyceridemia(1)
          Hodgkin Disease(1)
          Lymphoma(1)
          (skip...)

Phase 3:Ongoing:
          Lymphoma(5)
          Melanoma(4)
          Carcinoma, Non-Small-Cell Lung(4)
          Lung Neoplasms(4)
          Lymphoma, Follicular(3)
          Lymphoma, B-Cell(2)
          Hemoglobinuria, Paroxysmal(2)
          Hemoglobinuria(2)
          Macular Edema(2)
          Eosinophilic Esophagitis(2)
          Carcinoma(2)
          (skip...)

Phase 3:Finished:
          Dermatitis(10)
          Hypercholesterolemia(10)
          Dermatitis, Atopic(9)
          Hyperlipoproteinemia Type II(6)
          (6)
          Eczema(5)
          Osteoarthritis, Knee(4)
          Osteoarthritis(4)
          Osteoarthritis, Hip(3)
          COVID-19(2)
          Homozygous Familial Hypercholesterolemia(2)
          (skip...)

Phase 3:Aborted:
          COVID-19(2)
          Hemoglobinuria, Paroxysmal(2)
          Hemoglobinuria(2)
          Rhinitis, Allergic(1)
          Rhinitis(1)
          Ossification, Heterotopic(1)
          Myositis Ossificans(1)
          Carcinoma, Non-Small-Cell Lung(1)
          Lung Neoplasms(1)
          Low Back Pain(1)
          Back Pain(1)
          (skip...)

Phase 4:Ongoing:
          Eczema(1)
          Dermatitis(1)
          Dermatitis, Atopic(1)

Phase 4:Finished:
          Asthma(1)
          Vascular Diseases(1)
          Hypercholesterolemia(1)
          Macular Degeneration(1)
          (1)

Phase 4:Aborted:
          Hypercholesterolemia(1)
          Hyperlipoproteinemia Type II(1)

Phase Not Applicable:Ongoing:
          Celiac Disease(1)

Phase Not Applicable:Finished:
          Hemorrhage(1)

Phase Not Applicable:Aborted:
          Non-alcoholic Fatty Liver Disease(1)
          Fatty Liver(1)

ALL 17 33 26 1 7 - - 1
2024 2 5 1 - - - - -
2023 4 6 11 - 1 - - 1
2022 4 4 3 1 - - - -
GILD
(Gilead Sciences Inc.)
biological products (diagnostic and non diagnostic)
Insider Trading
Institutional Holding
Phase 1:Ongoing:
          Neoplasms(6)
          Hepatitis D, Chronic(2)
          Hepatitis D(2)
          Lymphoma, B-Cell(2)
          Lymphoma(2)
          Lupus Erythematosus, Systemic(1)
          Arthritis, Rheumatoid(1)
          Arthritis(1)
          Hepatitis, Chronic(1)
          Hepatitis(1)
          Hepatitis B, Chronic(1)
          (skip...)

Phase 1:Finished:
          Hepatitis C(12)
          Hepatitis(10)
          Hepatitis A(8)
          HIV Infections(8)
          Hepatitis C, Chronic(6)
          Long QT Syndrome(5)
          Fibrosis(5)
          Leukemia, Lymphocytic, Chronic, B-Cell(5)
          Renal Insufficiency(4)
          Arthritis, Rheumatoid(4)
          Arthritis(4)
          (skip...)

Phase 1:Abnormal:
          HIV Infections(1)

Phase 1:Aborted:
          Lymphoma(8)
          Leukemia(6)
          Neoplasms(5)
          Leukemia, Lymphoid(5)
          Leukemia, Lymphocytic, Chronic, B-Cell(4)
          Lymphoma, B-Cell(3)
          Neoplasms, Plasma Cell(3)
          Multiple Myeloma(3)
          Adenocarcinoma(3)
          Fibrosis(3)
          Lymphoma, Non-Hodgkin(3)
          (skip...)

Phase 2:Ongoing:
          Lymphoma(6)
          Triple Negative Breast Neoplasms(3)
          Breast Neoplasms(3)
          Neoplasms(3)
          Lymphoma, B-Cell(3)
          Lymphoma, Non-Hodgkin(3)
          (2)
          Colitis, Ulcerative(2)
          Colitis(2)
          HIV Infections(2)
          Carcinoma, Non-Small-Cell Lung(2)
          (skip...)

Phase 2:Finished:
          Hepatitis C(57)
          Hepatitis(45)
          Infections(35)
          Hepatitis A(32)
          Communicable Diseases(24)
          Hepatitis, Chronic(17)
          Hepatitis B(16)
          Hepatitis C, Chronic(15)
          Hepatitis B, Chronic(13)
          Lymphoma(13)
          HIV Infections(9)
          (skip...)

Phase 2:Abnormal:
          HIV Infections(1)

Phase 2:Aborted:
          Leukemia, Lymphocytic, Chronic, B-Cell(8)
          Lymphoma(8)
          Leukemia, Lymphoid(7)
          Leukemia(7)
          Fibrosis(5)
          Lymphoma, Non-Hodgkin(5)
          Hepatitis(4)
          Colorectal Neoplasms(3)
          Hepatitis A(3)
          Lymphoma, Large B-Cell, Diffuse(3)
          Hepatitis C(3)
          (skip...)

Phase 3:Ongoing:
          HIV Infections(6)
          Breast Neoplasms(5)
          Communicable Diseases(4)
          Infections(4)
          Acquired Immunodeficiency Syndrome(4)
          Triple Negative Breast Neoplasms(3)
          Lymphoma(3)
          Carcinoma, Non-Small-Cell Lung(2)
          Lung Neoplasms(2)
          Lymphoma, B-Cell(2)
          Immunologic Deficiency Syndromes(2)
          (skip...)

Phase 3:Finished:
          Hepatitis C(43)
          Infections(33)
          Hepatitis(33)
          HIV Infections(26)
          Communicable Diseases(21)
          Hepatitis A(19)
          Acquired Immunodeficiency Syndrome(13)
          Hepatitis B(13)
          Hepatitis C, Chronic(11)
          Immunologic Deficiency Syndromes(10)
          Fibrosis(9)
          (skip...)

Phase 3:Abnormal:
          Lymphoma, Non-Hodgkin(2)
          Lymphoma(2)
          HIV Infections(1)

Phase 3:Aborted:
          Leukemia(6)
          COVID-19(4)
          Leukemia, Lymphocytic, Chronic, B-Cell(4)
          Leukemia, Lymphoid(4)
          Lymphoma(3)
          Fibrosis(3)
          Hypertension(3)
          Leukemia, Myeloid, Acute(2)
          Leukemia, Myeloid(2)
          Spondylitis, Ankylosing(2)
          Spondylitis(2)
          (skip...)

Phase 4:Ongoing:
          Infections(1)
          Neoplasms(1)

Phase 4:Finished:
          HIV Infections(12)
          Infections(4)
          Hepatitis, Chronic(3)
          Hepatitis(3)
          Hepatitis B, Chronic(3)
          Hepatitis B(3)
          Myocardial Ischemia(2)
          Hepatitis A(2)
          Angina Pectoris(2)
          Hepatitis C(1)
          Diabetes Mellitus(1)
          (skip...)

Phase 4:Aborted:
          Coronary Disease(2)
          Myocardial Ischemia(2)
          Coronary Artery Disease(2)
          Neoplasms(1)
          Hepatitis(1)
          Hepatitis B, Chronic(1)
          Hepatitis B(1)
          Hepatitis A(1)
          Diabetes Mellitus(1)
          Angina, Stable(1)
          Angina Pectoris(1)
          (skip...)

Phase Not Applicable:Finished:
          HIV Infections(5)
          Acquired Immunodeficiency Syndrome(2)
          Infections(2)
          Herpes Simplex(1)
          Retinitis(1)
          Cytomegalovirus Retinitis(1)

Phase Not Applicable:Abnormal:
          HIV Infections(1)
          Retinitis(1)
          Cytomegalovirus Retinitis(1)

Phase Not Applicable:Aborted:
          Hepatitis(1)
          Hepatitis B(1)

ALL 16 32 23 3 17 - 6 9
2024 - 2 1 1 - - - -
2023 8 4 1 1 - - - -
2022 1 7 7 - 2 - - -
INCY
(Incyte Corp.)
commercial physical/biological research or service
Insider Trading
Institutional Holding
Phase 1:Ongoing:
          Neoplasms(15)
          Myeloproliferative Disorders(4)
          Carcinoma(4)
          Carcinoma, Squamous Cell(3)
          Carcinoma, Renal Cell(2)
          Small Cell Lung Carcinoma(2)
          Carcinoma, Merkel Cell(2)
          Neurodermatitis(1)
          Prurigo(1)
          Microsatellite Instability(1)
          Colorectal Neoplasms(1)
          (skip...)

Phase 1:Finished:
          Neoplasms(9)
          Renal Insufficiency(4)
          Lymphoma(4)
          Lymphoma, B-Cell(3)
          Eczema(3)
          Dermatitis(3)
          Dermatitis, Atopic(3)
          Kidney Diseases(2)
          Carcinoma(2)
          Graft vs Host Disease(2)
          Hematologic Neoplasms(2)
          (skip...)

Phase 1:Aborted:
          Carcinoma, Non-Small-Cell Lung(2)
          Carcinoma(2)
          Mesothelioma(1)
          Sarcoma, Ewing(1)
          Sarcoma(1)
          Graft vs Host Disease(1)
          Hematologic Neoplasms(1)
          Nasopharyngeal Carcinoma(1)
          Nasopharyngeal Neoplasms(1)
          Cholangiocarcinoma(1)
          Carcinoma, Hepatocellular(1)
          (skip...)

Phase 2:Ongoing:
          Neoplasms(5)
          Lymphoma(4)
          Thrombocytosis(2)
          Polycythemia(2)
          Primary Myelofibrosis(2)
          Anemia(2)
          Polycythemia Vera(2)
          Carcinoma(2)
          Leukemia, Lymphoid(2)
          Leukemia(2)
          Chronic Urticaria(1)
          (skip...)

Phase 2:Finished:
          Primary Myelofibrosis(8)
          Polycythemia Vera(5)
          Hidradenitis(4)
          Hidradenitis Suppurativa(4)
          Carcinoma, Non-Small-Cell Lung(4)
          Vitiligo(4)
          Carcinoma(4)
          Myeloproliferative Disorders(4)
          Psoriasis(4)
          Thrombocytosis(4)
          Polycythemia(4)
          (skip...)

Phase 2:Aborted:
          Neoplasms(11)
          Carcinoma(3)
          Hematologic Neoplasms(3)
          Carcinoma, Non-Small-Cell Lung(3)
          Breast Neoplasms(3)
          Myeloproliferative Disorders(3)
          Carcinoma, Transitional Cell(2)
          Multiple Myeloma(2)
          Lung Neoplasms(2)
          Syndrome(2)
          Thrombocythemia, Essential(2)
          (skip...)

Phase 3:Ongoing:
          Thrombocythemia, Essential(4)
          Thrombocytosis(4)
          Polycythemia(4)
          Primary Myelofibrosis(4)
          Polycythemia Vera(4)
          Hidradenitis(3)
          Hidradenitis Suppurativa(3)
          Carcinoma(3)
          Vitiligo(2)
          Prurigo(2)
          Eczema(2)
          (skip...)

Phase 3:Finished:
          Vitiligo(3)
          Eczema(3)
          Dermatitis(3)
          Dermatitis, Atopic(3)
          Polycythemia Vera(3)
          Carcinoma, Transitional Cell(2)
          Graft vs Host Disease(2)
          Polycythemia(2)
          Carcinoma(1)
          Melanoma(1)
          Myeloproliferative Disorders(1)
          (skip...)

Phase 3:Aborted:
          Eczema(2)
          Lymphoma(2)
          Carcinoma, Non-Small-Cell Lung(2)
          Lung Neoplasms(2)
          Pancreatic Neoplasms(2)
          Lymphoma, Mantle-Cell(1)
          Lymphoma, B-Cell, Marginal Zone(1)
          Lymphoma, Follicular(1)
          COVID-19(1)
          Graft vs Host Disease(1)
          Bronchiolitis Obliterans Syndrome(1)
          (skip...)

Phase 4:Ongoing:
          Eczema(1)
          Dermatitis(1)
          Dermatitis, Atopic(1)
          Parasomnias(1)
          Dyssomnias(1)

ALL 23 26 22 1 3 - - 1
2024 6 - 3 - - - - -
2023 7 7 4 1 1 - - -
2022 2 1 4 - - - - -
BGNE
(BeiGene Ltd.)
pharmaceuticals
Insider Trading
Institutional Holding
Phase 1:Ongoing:
          Neoplasms(13)
          Breast Neoplasms(3)
          Carcinoma, Non-Small-Cell Lung(2)
          Lymphoma(2)
          Autoimmune Diseases(1)
          Endometrial Neoplasms(1)
          Small Cell Lung Carcinoma(1)
          Stomach Neoplasms(1)
          Ovarian Neoplasms(1)
          Prostatic Neoplasms(1)
          Lung Neoplasms(1)
          (skip...)

Phase 1:Finished:
          Neoplasms(8)
          Lymphoma, B-Cell(2)
          Lymphoma(2)
          Neuroblastoma(1)
          COVID-19(1)
          Lymphoma, Large B-Cell, Diffuse(1)
          Liver Failure(1)
          Hepatic Insufficiency(1)

Phase 1:Aborted:
          Neoplasms(1)

Phase 2:Ongoing:
          Lymphoma(9)
          Neoplasms(5)
          Carcinoma, Non-Small-Cell Lung(4)
          Lung Neoplasms(4)
          Carcinoma(4)
          Lymphoma, Large B-Cell, Diffuse(4)
          Lymphoma, Mantle-Cell(4)
          Leukemia, Lymphocytic, Chronic, B-Cell(4)
          Carcinoma, Squamous Cell(3)
          Waldenstrom Macroglobulinemia(3)
          Colorectal Neoplasms(2)
          (skip...)

Phase 2:Finished:
          Lymphoma(7)
          Carcinoma(6)
          Neoplasms(4)
          Carcinoma, Hepatocellular(3)
          COVID-19(2)
          Lymphoma, B-Cell, Marginal Zone(2)
          Esophageal Squamous Cell Carcinoma(2)
          Lung Neoplasms(2)
          Stomach Neoplasms(2)
          Breast Neoplasms(2)
          Lymphoma, Large B-Cell, Diffuse(2)
          (skip...)

Phase 2:Aborted:
          Esophageal Squamous Cell Carcinoma(1)
          Carcinoma, Squamous Cell(1)
          Carcinoma(1)
          Prostatic Neoplasms(1)
          Neoplasms(1)

Phase 3:Ongoing:
          Lymphoma(4)
          Lung Neoplasms(3)
          Carcinoma(3)
          Carcinoma, Non-Small-Cell Lung(2)
          Neoplasms(2)
          Esophageal Squamous Cell Carcinoma(2)
          Carcinoma, Squamous Cell(2)
          Leukemia, Lymphocytic, Chronic, B-Cell(2)
          Leukemia, Lymphoid(2)
          Leukemia(2)
          Glomerulonephritis, Membranous(1)
          (skip...)

Phase 3:Finished:
          Carcinoma, Non-Small-Cell Lung(3)
          Lung Neoplasms(3)
          Carcinoma(2)
          Leukemia, Lymphocytic, Chronic, B-Cell(1)
          Leukemia, Lymphoid(1)
          Leukemia(1)
          Lymphoma(1)
          Esophageal Squamous Cell Carcinoma(1)
          Carcinoma, Squamous Cell(1)
          Carcinoma, Hepatocellular(1)
          Waldenstrom Macroglobulinemia(1)
          (skip...)

Phase 3:Aborted:
          Carcinoma, Non-Small-Cell Lung(2)
          Lung Neoplasms(2)
          Carcinoma, Hepatocellular(1)
          Carcinoma(1)

ALL 19 28 17 - 1 - - -
2024 4 - - - - - - -
2023 6 4 2 - - - - -
2022 3 7 - - - - - -
BIIB
(Biogen Idec Inc.)
biological products (diagnostic and non diagnostic)
Insider Trading
Institutional Holding
Phase 1:Ongoing:
          Friedreich Ataxia(1)
          Cerebellar Ataxia(1)
          Ataxia(1)
          Muscular Atrophy, Spinal(1)
          Muscular Atrophy(1)
          Parkinson Disease(1)

Phase 1:Finished:
          Multiple Sclerosis(13)
          Sclerosis(8)
          Neoplasms(7)
          Neuralgia(5)
          Schizophrenia(4)
          Atrophy(4)
          Alzheimer Disease(4)
          Multiple Sclerosis, Relapsing-Remitting(4)
          Trigeminal Neuralgia(3)
          Muscular Atrophy, Spinal(3)
          Muscular Atrophy(3)
          (skip...)

Phase 1:Aborted:
          Diabetes Mellitus, Type 2(3)
          Diabetes Mellitus(3)
          Renal Insufficiency, Chronic(3)
          Kidney Diseases(3)
          Renal Insufficiency(2)
          Leukemia, Lymphocytic, Chronic, B-Cell(2)
          Leukemia, Lymphoid(2)
          Leukemia(2)
          Machado-Joseph Disease(1)
          Spinocerebellar Degenerations(1)
          Spinocerebellar Ataxias(1)
          (skip...)

Phase 2:Ongoing:
          Sclerosis(2)
          Diabetic Neuropathies(1)
          Neuralgia(1)
          Multiple Sclerosis(1)
          Cognitive Dysfunction(1)
          Dementia(1)
          Alzheimer Disease(1)
          Parkinson Disease(1)
          Disease Progression(1)
          Amyotrophic Lateral Sclerosis(1)
          Motor Neuron Disease(1)
          (skip...)

Phase 2:Finished:
          Multiple Sclerosis(15)
          Sclerosis(14)
          Multiple Sclerosis, Relapsing-Remitting(9)
          Kidney Diseases(5)
          Stroke(4)
          Renal Insufficiency, Chronic(4)
          Radiculopathy(3)
          Neuralgia(3)
          (3)
          Parkinson Disease(3)
          Arthritis, Rheumatoid(3)
          (skip...)

Phase 2:Aborted:
          Arthritis, Rheumatoid(7)
          Arthritis(7)
          Sclerosis(4)
          Multiple Sclerosis(4)
          Diabetes Mellitus(3)
          Alzheimer Disease(2)
          Cognitive Dysfunction(2)
          Diabetes Mellitus, Type 2(2)
          Lupus Nephritis(2)
          Nephritis(2)
          Renal Insufficiency(2)
          (skip...)

Phase 3:Ongoing:
          Lupus Erythematosus, Systemic(5)
          Sclerosis(4)
          Multiple Sclerosis(4)
          Atrophy(3)
          Muscular Atrophy, Spinal(3)
          Muscular Atrophy(3)
          Multiple Sclerosis, Relapsing-Remitting(3)
          Lupus Erythematosus, Discoid(2)
          Lupus Erythematosus, Cutaneous(2)
          Alzheimer Disease(2)
          Amyotrophic Lateral Sclerosis(1)
          (skip...)

Phase 3:Finished:
          Sclerosis(27)
          Multiple Sclerosis(26)
          Multiple Sclerosis, Relapsing-Remitting(16)
          Depressive Disorder(5)
          Depression(5)
          Depressive Disorder, Major(3)
          Crohn Disease(3)
          Depression, Postpartum(2)
          Atrophy(2)
          Muscular Atrophy, Spinal(2)
          Muscular Atrophy(2)
          (skip...)

Phase 3:Aborted:
          Sclerosis(10)
          Multiple Sclerosis(10)
          Multiple Sclerosis, Relapsing-Remitting(6)
          Lymphoma, Non-Hodgkin(3)
          Lymphoma(3)
          Depressive Disorder, Major(2)
          Depression(2)
          Depressive Disorder(2)
          Polycystic Kidney, Autosomal Dominant(2)
          Polycystic Kidney Diseases(2)
          Neuralgia(2)
          (skip...)

Phase 4:Ongoing:
          Sclerosis(1)
          Multiple Sclerosis(1)
          Atrophy(1)
          Muscular Atrophy, Spinal(1)
          Muscular Atrophy(1)

Phase 4:Finished:
          Multiple Sclerosis(24)
          Sclerosis(21)
          Multiple Sclerosis, Relapsing-Remitting(15)
          Lymphoma, Non-Hodgkin(2)
          Lymphoma(2)
          Injection Site Reaction(1)
          Flushing(1)
          Crohn Disease(1)

Phase 4:Aborted:
          Multiple Sclerosis(10)
          Sclerosis(9)
          Multiple Sclerosis, Relapsing-Remitting(7)
          Erythema(1)
          Fatigue(1)
          Syndrome(1)
          Immune Reconstitution Inflammatory Syndrome(1)
          Leukoencephalopathies(1)
          Leukoencephalopathy, Progressive Multifocal(1)
          Crohn Disease(1)

Phase Not Applicable:Ongoing:
          Atrophy(1)
          Muscular Atrophy, Spinal(1)
          Muscular Atrophy(1)

Phase Not Applicable:Finished:
          Atrophy(1)
          Neuromuscular Diseases(1)
          Muscular Atrophy, Spinal(1)
          Muscular Atrophy(1)
          Sclerosis(1)
          Multiple Sclerosis(1)

ALL 6 7 17 2 8 1 - 1
2024 3 - - - - - - -
2023 1 1 1 - 1 - - 1
2022 1 3 4 1 - - - -
ARGX
(argenx SE)
biological products (diagnostic and non diagnostic)
Insider Trading
Institutional Holding
Phase 1:Ongoing:
          Renal Insufficiency(1)

Phase 1:Finished:
          Nasopharyngeal Carcinoma(1)

Phase 2:Ongoing:
          Syndrome(4)
          Sjogren\'s Syndrome(2)
          Tachycardia(2)
          Postural Orthostatic Tachycardia Syndrome(2)
          Neuritis(2)
          Myositis(1)
          Dermatomyositis(1)
          Delayed Graft Function(1)
          Lupus Nephritis(1)
          Nephritis(1)
          Glomerulonephritis, Membranous(1)
          (skip...)

Phase 2:Finished:
          Polyradiculoneuropathy, Chronic Inflammatory Demyelinating(1)
          Polyneuropathies(1)
          Pemphigus(1)
          Purpura, Thrombocytopenic, Idiopathic(1)
          Thrombocytopenia(1)
          Myasthenia Gravis(1)
          Paresis(1)
          Muscle Weakness(1)

Phase 3:Ongoing:
          Muscle Weakness(5)
          Myasthenia Gravis(5)
          Thyroid Diseases(2)
          Graves Ophthalmopathy(2)
          Eye Diseases(2)
          Polymyositis(2)
          Myositis(2)
          Dermatomyositis(2)
          Muscular Diseases(2)
          Pemphigoid, Bullous(2)
          Purpura, Thrombocytopenic, Idiopathic(2)
          (skip...)

Phase 3:Finished:
          Muscle Weakness(3)
          Myasthenia Gravis(3)
          Purpura, Thrombocytopenic, Idiopathic(2)
          Thrombocytopenia(2)
          Paresis(2)
          Pemphigus(1)

Phase 3:Aborted:
          Purpura, Thrombocytopenic, Idiopathic(1)
          Thrombocytopenia(1)

ALL 2 11 14 - 1 - - 1
2024 - 1 3 - - - - -
2023 1 5 1 - - - - 1
2022 1 3 4 - - - - -
VRTX
(Vertex Pharmaceuticals Incorporated)
pharmaceuticals
Insider Trading
Institutional Holding
Phase 1:Ongoing:
          Cystic Fibrosis(4)
          Renal Insufficiency(2)
          Polycystic Kidney, Autosomal Dominant(1)
          Polycystic Kidney Diseases(1)
          Kidney Diseases(1)

Phase 1:Finished:
          Cystic Fibrosis(15)
          Hepatitis C(7)
          Alpha 1-Antitrypsin Deficiency(2)
          Hepatitis C, Chronic(2)
          Hepatitis(2)
          Hepatitis A(2)
          Glomerulosclerosis, Focal Segmental(1)
          Acute Pain(1)
          Kidney Diseases(1)
          Fibrosis(1)
          Liver Diseases(1)
          (skip...)

Phase 2:Ongoing:
          Diabetes Mellitus, Type 1(2)
          Diabetes Mellitus(2)
          Myotonic Dystrophy(1)
          (1)
          Radiculopathy(1)
          Fibrosis(1)
          Cystic Fibrosis(1)
          Alpha 1-Antitrypsin Deficiency(1)
          Hypoglycemia(1)

Phase 2:Finished:
          Fibrosis(19)
          Cystic Fibrosis(19)
          Hepatitis(13)
          Hepatitis C(13)
          Hepatitis A(13)
          Hepatitis C, Chronic(9)
          Arthritis, Rheumatoid(5)
          Arthritis(5)
          Acute Pain(4)
          Hepatitis, Chronic(4)
          Diabetic Neuropathies(1)
          (skip...)

Phase 2:Aborted:
          Hepatitis(3)
          Hepatitis C(3)
          Hepatitis A(2)
          Fibrosis(2)
          Cystic Fibrosis(2)
          Alpha 1-Antitrypsin Deficiency(1)
          Epilepsies, Partial(1)
          Epilepsy(1)
          Virus Diseases(1)
          Hepatitis C, Chronic(1)
          Infections(1)
          (skip...)

Phase 3:Ongoing:
          Fibrosis(6)
          Cystic Fibrosis(6)
          Hemoglobinopathies(6)
          Hematologic Diseases(6)
          Anemia, Sickle Cell(5)
          Genetic Diseases, Inborn(4)
          beta-Thalassemia(4)
          Thalassemia(4)
          Kidney Diseases(1)

Phase 3:Finished:
          Fibrosis(52)
          Cystic Fibrosis(52)
          Acute Pain(3)
          Hepatitis(2)
          Hepatitis C(2)
          Hepatitis A(2)
          Lung Diseases(1)
          Arthritis, Rheumatoid(1)
          Arthritis(1)
          Hepatitis C, Chronic(1)

Phase 3:Aborted:
          Fibrosis(3)
          Cystic Fibrosis(3)
          Hepatitis(2)
          Hepatitis C(2)
          Wounds and Injuries(1)
          Spinal Cord Injuries(1)
          Hepatitis A(1)
          Hepatitis C, Chronic(1)

Phase 4:Finished:
          Fibrosis(1)
          Cystic Fibrosis(1)

Phase 4:Aborted:
          Cystic Fibrosis(1)
          Hepatitis(1)
          Hepatitis C, Chronic(1)
          Hepatitis C(1)
          Hepatitis A(1)

Phase Not Applicable:Aborted:
          Neoplasms(1)

ALL 10 6 14 - 5 - 3 -
2024 5 - - - - - - -
2023 5 3 3 - - - 1 -
2022 - 2 7 - - - - -
SBFM
(Sunshine Biopharma Inc.)
pharmaceuticals
Insider Trading
Institutional Holding
Phase 1:Ongoing:
          Renal Insufficiency, Chronic(3)
          Kidney Diseases(3)
          Diabetes Mellitus, Type 2(2)
          Sleep Initiation and Maintenance Disorders(2)
          Pulmonary Eosinophilia(2)
          Arthritis, Gouty(1)
          Asthma(1)
          Thrombocytopenia(1)
          Liver Diseases(1)
          Familial Mediterranean Fever(1)
          Arthritis, Juvenile(1)
          (skip...)

Phase 1:Finished:
          Hepatitis C, Chronic(6)
          Hepatitis C(6)
          Idiopathic Pulmonary Fibrosis(4)
          Pulmonary Fibrosis(4)
          Non-alcoholic Fatty Liver Disease(3)
          Fatty Liver(3)
          Hepatitis B, Chronic(3)
          Hepatitis B(3)
          Depressive Disorder, Major(2)
          Depressive Disorder(2)
          Neoplasms(2)
          (skip...)

Phase 1:Abnormal:
          Colorectal Neoplasms(1)
          Kidney Failure, Chronic(1)

Phase 1:Aborted:
          Pancreatic Neoplasms(1)
          Leukemia, Myeloid, Acute(1)
          Leukemia, Myeloid(1)
          Leukemia(1)

Phase 2:Ongoing:
          Carcinoma, Non-Small-Cell Lung(3)
          Spondylarthritis(2)
          Spondylitis(2)
          Arthritis, Gouty(2)
          Lung Diseases(2)
          Sarcoma(2)
          Pulmonary Fibrosis(2)
          Retinal Vein Occlusion(2)
          Dermatitis(1)
          Dermatitis, Atopic(1)
          Arthritis(1)
          (skip...)

Phase 2:Finished:
          Dermatitis(2)
          Dermatitis, Atopic(2)
          Hepatitis C(2)
          Non-alcoholic Fatty Liver Disease(1)
          Fatty Liver(1)
          Hepatitis C, Chronic(1)
          Esophageal Squamous Cell Carcinoma(1)
          Carcinoma, Squamous Cell(1)
          Carcinoma(1)
          Hepatitis, Chronic(1)
          Hepatitis(1)
          (skip...)

Phase 2:Abnormal:
          Hepatitis(1)
          Hepatitis B, Chronic(1)
          Hepatitis B(1)
          Hepatitis A(1)

Phase 2:Aborted:
          Carcinoma, Renal Cell(1)

Phase 3:Ongoing:
          Psoriasis(2)
          Asthma(1)
          Dermatitis(1)
          Dermatitis, Atopic(1)
          Arthritis, Gouty(1)
          (1)
          Diabetes Mellitus(1)
          Leukemia, Myeloid, Acute(1)
          Leukemia(1)
          Retinal Vein Occlusion(1)
          Hepatitis C(1)
          (skip...)

Phase 3:Finished:
          Spondylitis, Ankylosing(1)
          Spondylitis(1)
          Hepatitis C(1)
          Infections(1)
          Anemia(1)

Phase 4:Ongoing:
          Fibrosis(1)
          Bronchiectasis(1)
          Cystic Fibrosis(1)
          Burkholderia Infections(1)
          HIV Infections(1)

Phase 4:Finished:
          Purpura, Thrombocytopenic, Idiopathic(1)
          Thrombocytopenia(1)

Phase 4:Aborted:
          Anemia(1)

Phase Not Applicable:Finished:
          Genetic Diseases, X-Linked(1)
          Parkinsonian Disorders(1)
          Dystonic Disorders(1)
          Dystonia(1)

ALL 27 24 13 2 - - - 31
2024 - 5 2 - - - - -
2023 1 2 3 1 - - - 1
2022 3 4 5 1 - - - 3
IONS
(Ionis Pharmaceuticals Inc.)
pharmaceuticals
Insider Trading
Institutional Holding
Phase 1:Ongoing:
          Pelizaeus-Merzbacher Disease(1)
          Neoplasms, Plasma Cell(1)
          Multiple Myeloma(1)
          Atrophy(1)
          Shy-Drager Syndrome(1)
          Multiple System Atrophy(1)

Phase 1:Finished:
          Diabetes Mellitus, Type 2(3)
          Hypertriglyceridemia(2)
          Neoplasms(1)
          Fibrosis(1)
          Cystic Fibrosis(1)
          Thalassemia(1)
          Cardiovascular Abnormalities(1)
          Hypercholesterolemia(1)
          Hyperlipoproteinemia Type II(1)
          Sclerosis(1)
          Amyotrophic Lateral Sclerosis(1)
          (skip...)

Phase 2:Ongoing:
          Prion Diseases(1)
          Polycythemia(1)
          Polycythemia Vera(1)
          Syndrome(1)
          Angelman Syndrome(1)
          Angioedemas, Hereditary(1)
          Angioedema(1)
          Glomerulonephritis, IGA(1)
          Kidney Diseases(1)
          Atrophy(1)
          Geographic Atrophy(1)
          (skip...)

Phase 2:Finished:
          Diabetes Mellitus, Type 2(8)
          Diabetes Mellitus(7)
          Hypertension(4)
          Acromegaly(3)
          Fatty Liver(2)
          Kidney Failure, Chronic(2)
          Kidney Diseases(2)
          Hypertriglyceridemia(2)
          (2)
          Colitis, Ulcerative(2)
          Colitis(2)
          (skip...)

Phase 2:Aborted:
          Diabetes Mellitus, Type 2(3)
          Diabetes Mellitus(3)
          Acute Disease(1)
          Pulmonary Disease, Chronic Obstructive(1)
          Lung Diseases, Obstructive(1)
          Lung Diseases(1)
          Bronchitis, Chronic(1)
          Bronchitis(1)
          beta-Thalassemia(1)
          Thalassemia(1)
          Atrophy(1)
          (skip...)

Phase 3:Ongoing:
          Hypertriglyceridemia(4)
          Amyloidosis(3)
          Syndrome(2)
          Hyperlipoproteinemia Type I(2)
          Cardiomyopathies(2)
          Atherosclerosis(1)
          Cardiovascular Diseases(1)
          Angioedemas, Hereditary(1)
          Angioedema(1)
          Amyloid Neuropathies(1)
          Polyneuropathies(1)
          (skip...)

Phase 3:Finished:
          Amyloidosis(3)
          Amyloid Neuropathies(3)
          Polyneuropathies(3)
          Syndrome(2)
          Hyperlipoproteinemia Type I(2)
          Amyloid Neuropathies, Familial(2)
          Crohn Disease(2)
          Angioedemas, Hereditary(1)
          Angioedema(1)
          Hypertriglyceridemia(1)
          Carcinoma, Non-Small-Cell Lung(1)
          (skip...)

Phase Not Applicable:Finished:
          Retinitis(2)
          Cytomegalovirus Retinitis(2)

ALL 3 6 12 - - - - -
2024 - - - - - - - -
2023 1 1 - - - - - -
2022 - - 5 - - - - -
VNDA
(Vanda Pharmaceuticals Inc.)
pharmaceuticals
Insider Trading
Institutional Holding
Phase 1:Ongoing:
          Hematologic Neoplasms(1)
          Neoplasms(1)

Phase 1:Finished:
          Schizophrenia(2)
          Autism Spectrum Disorder(1)
          Smith-Magenis Syndrome(1)
          Sleep Disorders, Circadian Rhythm(1)
          Sleep Wake Disorders(1)
          Pruritus(1)
          Renal Insufficiency(1)
          Liver Diseases(1)

Phase 2:Ongoing:
          Keratoconjunctivitis Sicca(1)
          Dry Eye Syndromes(1)

Phase 2:Finished:
          Pruritus(2)
          Eczema(2)
          Dermatitis(2)
          Dermatitis, Atopic(2)
          Anxiety Disorders(1)
          Conjunctivitis, Allergic(1)
          Conjunctivitis(1)
          Motion Sickness(1)
          Jet Lag Syndrome(1)
          Sleep Disorders, Circadian Rhythm(1)
          Sleep Wake Disorders(1)
          (skip...)

Phase 2:Abnormal:
          Gastroparesis(1)

Phase 2:Aborted:
          Mental Disorders(1)
          Psychotic Disorders(1)
          Parkinson Disease(1)

Phase 3:Ongoing:
          Sleep Wake Disorders(3)
          Motion Sickness(2)
          Sleep Disorders, Circadian Rhythm(2)
          Autism Spectrum Disorder(1)
          Autistic Disorder(1)
          Nervous System Diseases(1)
          Dyssomnias(1)
          Parasomnias(1)
          Chronobiology Disorders(1)
          Severe Acute Respiratory Syndrome(1)
          Coronavirus Infections(1)
          (skip...)

Phase 3:Finished:
          Disease(4)
          Sleep Disorders, Circadian Rhythm(3)
          Sleep Wake Disorders(3)
          Sleep Initiation and Maintenance Disorders(3)
          Eczema(2)
          Dermatitis(2)
          Dermatitis, Atopic(2)
          Schizophrenia(2)
          Motion Sickness(1)
          Jet Lag Syndrome(1)
          Syndrome(1)
          (skip...)

Phase 4:Ongoing:
          Schizophrenia(1)

Phase 4:Finished:
          Sleep Disorders, Circadian Rhythm(1)
          Sleep Wake Disorders(1)

ALL 1 1 7 1 2 - 1 -
2024 - 1 - - - - - -
2023 - - 2 - - - - -
2022 - - - 1 - - - -
AXSM
(Axsome Therapeutics Inc.)
pharmaceuticals
Insider Trading
Institutional Holding
Phase 1:Finished:
          Sleepiness(1)
          Disorders of Excessive Somnolence(1)
          Narcolepsy(1)
          Sleep Apnea, Obstructive(1)

Phase 2:Ongoing:
          Depressive Disorder, Treatment-Resistant(1)
          Depressive Disorder, Major(1)
          Depressive Disorder(1)
          Depression(1)

Phase 2:Finished:
          Depressive Disorder, Major(3)
          Depression(3)
          Depressive Disorder(3)
          Depressive Disorder, Treatment-Resistant(2)
          Sleepiness(1)
          Cataplexy(1)
          Narcolepsy(1)

Phase 3:Ongoing:
          Psychomotor Agitation(2)
          Alzheimer Disease(2)
          Depressive Disorder, Major(1)
          Depression(1)
          Depressive Disorder(1)
          Dementia(1)
          Migraine Disorders(1)
          Sleepiness(1)
          Cataplexy(1)
          Disorders of Excessive Somnolence(1)
          Narcolepsy(1)
          (skip...)

Phase 3:Finished:
          Migraine Disorders(3)
          Depressive Disorder, Major(3)
          Depression(3)
          Depressive Disorder(3)
          Psychomotor Agitation(2)
          Dementia(2)
          Alzheimer Disease(2)
          Disease(2)
          Sleepiness(1)
          Cataplexy(1)
          Disorders of Excessive Somnolence(1)
          (skip...)

Phase 3:Abnormal:
          Syndrome(1)
          Reflex Sympathetic Dystrophy(1)
          Complex Regional Pain Syndromes(1)

Phase 4:Ongoing:
          Depressive Disorder, Major(1)
          Depression(1)
          Depressive Disorder(1)
          Recurrence(1)

Phase 4:Finished:
          Sleepiness(1)
          Disorders of Excessive Somnolence(1)
          Sleep Apnea, Obstructive(1)
          Sleep Apnea Syndromes(1)
          (1)

ALL - 1 7 1 1 - 1 -
2024 - - 1 1 - - - -
2023 - - 1 - - - - -
2022 - - 2 - - - 1 -
RARE
(Ultragenyx Pharmaceutical Inc.)
pharmaceuticals
Insider Trading
Institutional Holding
Phase 1:Finished:
          Distal Myopathies(1)
          Muscular Diseases(1)

Phase 2:Ongoing:
          Hepatolenticular Degeneration(1)
          Syndrome(1)
          Angelman Syndrome(1)

Phase 2:Finished:
          Syndrome(2)
          Mucopolysaccharidoses(2)
          Distal Myopathies(2)
          Muscular Diseases(2)
          Osteogenesis Imperfecta(2)
          Glycogen Storage Disease(1)
          Mucopolysaccharidosis VII(1)
          Carbohydrate Metabolism, Inborn Errors(1)
          Disease(1)
          Hypophosphatasia(1)
          Bone Diseases, Metabolic(1)
          (skip...)

Phase 2:Aborted:
          Osteogenesis Imperfecta(2)
          Disease(1)
          Glycogen Storage Disease Type III(1)
          Glycogen Storage Disease(1)
          Mucopolysaccharidosis III(1)
          Mucopolysaccharidoses(1)
          Distal Myopathies(1)
          Muscular Diseases(1)
          Hemophilia B(1)
          Hemophilia A(1)
          Syndrome(1)
          (skip...)

Phase 3:Ongoing:
          Osteogenesis Imperfecta(2)
          Mucopolysaccharidosis III(2)
          Mucopolysaccharidoses(2)
          Ornithine Carbamoyltransferase Deficiency Disease(1)
          Disease(1)
          Metabolic Diseases(1)
          Glycogen Storage Disease Type I(1)
          Glycogen Storage Disease(1)

Phase 3:Finished:
          Mucopolysaccharidosis VII(2)
          Mucopolysaccharidoses(2)
          Syndrome(1)
          Distal Myopathies(1)
          Muscular Diseases(1)

Phase 3:Aborted:
          Syndrome(1)
          Carbohydrate Metabolism, Inborn Errors(1)
          Movement Disorders(1)
          Distal Myopathies(1)
          Muscular Diseases(1)

ALL - 2 7 - 2 - - -
2024 - - - - - - - -
2023 - - 2 - - - - -
2022 - - 1 - - - - -
ACAD
(ACADIA Pharmaceuticals Inc.)
pharmaceuticals
Insider Trading
Institutional Holding
Phase 2:Finished:
          Schizophrenia(3)
          Mental Disorders(3)
          Psychotic Disorders(3)
          Parkinson Disease(3)
          Depression(2)
          Depressive Disorder(2)
          Alzheimer Disease(2)
          Pain, Postoperative(1)
          Aggression(1)
          Psychomotor Agitation(1)
          Depressive Disorder, Major(1)
          (skip...)

Phase 2:Aborted:
          Osteoarthritis, Knee(1)
          Osteoarthritis(1)
          Parkinson Disease(1)
          Aggression(1)
          Psychomotor Agitation(1)
          Alzheimer Disease(1)

Phase 3:Ongoing:
          Mental Disorders(2)
          Psychotic Disorders(2)
          Alzheimer Disease(2)
          Child Development Disorders, Pervasive(2)
          Autism Spectrum Disorder(2)
          Autistic Disorder(2)
          Schizophrenia(2)
          Hyperphagia(1)
          Syndrome(1)
          Prader-Willi Syndrome(1)

Phase 3:Finished:
          Mental Disorders(5)
          Psychotic Disorders(5)
          Syndrome(4)
          Rett Syndrome(4)
          Parkinson Disease(4)
          Depressive Disorder, Major(2)
          Depression(2)
          Depressive Disorder(2)
          Neurodegenerative Diseases(2)
          Dementia(1)
          Schizophrenia(1)
          (skip...)

Phase 3:Aborted:
          Depressive Disorder, Major(1)
          Depression(1)
          Depressive Disorder(1)

Phase 4:Finished:
          Mental Disorders(1)
          Psychotic Disorders(1)
          Parkinson Disease(1)

ALL - - 7 - 2 - 1 -
2024 - - - - - - - -
2023 - - 3 - 1 - - -
2022 - - 2 - - - - -
KRTX
(Karuna Therapeutics Inc.)
pharmaceuticals
Insider Trading
Institutional Holding
Phase 1:Finished:
          Schizophrenia(1)

Phase 2:Finished:
          Schizophrenia(1)

Phase 3:Ongoing:
          Schizophrenia(4)
          Mental Disorders(3)
          Psychotic Disorders(3)
          Alzheimer Disease(3)

Phase 3:Finished:
          Schizophrenia(3)

Phase 3:Aborted:
          Schizophrenia(1)

Phase Not Applicable:Finished:
          Chronic Pain(1)
          Low Back Pain(1)
          Shoulder Pain(1)

ALL - - 7 - - - - -
2024 - - - - - - - -
2023 - - 3 - - - - -
2022 - - 2 - - - - -
EXEL
(Exelixis Inc.)
biological products (diagnostic and non diagnostic)
Insider Trading
Institutional Holding
Phase 1:Ongoing:
          Neoplasms(3)
          Breast Neoplasms(3)
          Carcinoma, Ovarian Epithelial(2)
          Triple Negative Breast Neoplasms(2)
          Carcinoma, Renal Cell(2)
          Carcinoma(2)
          Squamous Cell Carcinoma of Head and Neck(1)
          Endometrial Neoplasms(1)

Phase 1:Finished:
          Thyroid Neoplasms(3)
          Thyroid Cancer, Papillary(2)
          Renal Insufficiency(1)
          Liver Diseases(1)
          Thyroid Diseases(1)
          Adenocarcinoma, Follicular(1)
          Carcinoma, Renal Cell(1)
          Gliosarcoma(1)
          Glioblastoma(1)
          Neoplasms(1)

Phase 1:Abnormal:
          Neoplasms(1)

Phase 1:Aborted:
          Polycythemia(2)
          Polycythemia Vera(2)
          Neoplasms(2)
          Leukemia, Lymphocytic, Chronic, B-Cell(2)
          Leukemia, Lymphoid(2)
          Leukemia(2)
          Lymphoma, Large B-Cell, Diffuse(1)
          Lymphoma, Mantle-Cell(1)
          Lymphoma, Non-Hodgkin(1)
          Lymphoma(1)
          Carcinoma, Non-Small-Cell Lung(1)
          (skip...)

Phase 2:Ongoing:
          Carcinoma, Renal Cell(2)
          Carcinoma(2)
          Triple Negative Breast Neoplasms(1)
          Endometrial Neoplasms(1)

Phase 2:Finished:
          Glioblastoma(2)
          Astrocytoma(1)
          Carcinoma, Non-Small-Cell Lung(1)
          Lung Neoplasms(1)
          Digestive System Neoplasms(1)
          Gastrointestinal Neoplasms(1)
          Gastrointestinal Stromal Tumors(1)

Phase 2:Aborted:
          Prostatic Neoplasms(1)

Phase 3:Ongoing:
          Carcinoma(4)
          Carcinoma, Renal Cell(2)
          Squamous Cell Carcinoma of Head and Neck(1)
          Carcinoma, Squamous Cell(1)
          Colorectal Neoplasms(1)
          Prostatic Neoplasms(1)
          Carcinoma, Hepatocellular(1)
          Thyroid Diseases(1)
          Thyroid Neoplasms(1)

Phase 3:Finished:
          Carcinoma(2)
          Carcinoma, Hepatocellular(1)
          Carcinoma, Renal Cell(1)
          Prostatic Neoplasms(1)
          Thyroid Diseases(1)
          Thyroid Neoplasms(1)

Phase 3:Aborted:
          Prostatic Neoplasms(1)

Phase 4:Ongoing:
          Thyroid Diseases(1)
          Carcinoma, Neuroendocrine(1)
          Thyroid Neoplasms(1)

ALL 5 2 7 1 1 - 1 -
2024 - - - - - - - -
2023 1 1 1 - - - - -
2022 - - 2 - - - - -
ITCI
(Intra-Cellular Therapies Inc.)
pharmaceuticals
Insider Trading
Institutional Holding
Phase 1:Finished:
          Schizophrenia(2)
          Psychotic Disorders(1)

Phase 2:Ongoing:
          Parkinson Disease(1)

Phase 2:Finished:
          Schizophrenia(2)
          Heart Failure, Systolic(1)
          Heart Failure(1)
          Parkinson Disease(1)
          Dementia(1)
          Alzheimer Disease(1)

Phase 3:Ongoing:
          Depression(5)
          Depressive Disorder(5)
          Depressive Disorder, Major(4)
          Bipolar Disorder(2)
          Schizophrenia(2)
          Recurrence(1)

Phase 3:Finished:
          Bipolar Disorder(4)
          Depressive Disorder(4)
          Depression(4)
          Schizophrenia(2)
          Depressive Disorder, Major(1)
          Disease(1)

Phase 3:Aborted:
          Psychomotor Agitation(1)
          Dementia(1)
          Alzheimer Disease(1)

ALL 3 1 7 - 1 - - -
2024 1 - 2 - - - - -
2023 1 1 1 - - - - -
2022 1 - - - - - - -
UTHR
(United Therapeutics Corporation)
pharmaceuticals
Insider Trading
Institutional Holding
Phase 1:Finished:
          Hypertension(7)
          Hypertension, Pulmonary(2)
          Familial Primary Pulmonary Hypertension(1)
          Pulmonary Arterial Hypertension(1)
          Renal Insufficiency(1)
          Sclerosis(1)
          Scleroderma, Diffuse(1)
          Scleroderma, Systemic(1)

Phase 1:Aborted:
          Bronchopulmonary Dysplasia(1)
          Hypertension(1)
          Familial Primary Pulmonary Hypertension(1)

Phase 2:Finished:
          Hypertension(5)
          Familial Primary Pulmonary Hypertension(4)
          Pulmonary Arterial Hypertension(2)
          Neuroblastoma(1)
          Hypertension, Pulmonary(1)
          Scleroderma, Localized(1)
          Scleroderma, Diffuse(1)
          Scleroderma, Systemic(1)

Phase 2:Abnormal:
          Hepatitis(1)
          Hepatitis C(1)
          Hepatitis A(1)

Phase 2:Aborted:
          Hypertension(4)
          Hypertension, Pulmonary(3)
          Familial Primary Pulmonary Hypertension(1)
          Pulmonary Disease, Chronic Obstructive(1)
          Lung Diseases, Obstructive(1)
          Lung Diseases(1)
          Fibrosis(1)
          Pulmonary Fibrosis(1)
          Persistent Fetal Circulation Syndrome(1)
          Neuroblastoma(1)
          Sclerosis(1)
          (skip...)

Phase 3:Ongoing:
          Lung Diseases(6)
          Fibrosis(4)
          Lung Diseases, Interstitial(4)
          Pulmonary Fibrosis(4)
          Idiopathic Pulmonary Fibrosis(3)
          Hypertension(2)
          Familial Primary Pulmonary Hypertension(2)
          Respiratory Tract Diseases(2)
          Pulmonary Arterial Hypertension(2)
          Hypertension, Pulmonary(2)

Phase 3:Finished:
          Hypertension(9)
          Hypertension, Pulmonary(6)
          Pulmonary Arterial Hypertension(4)
          Familial Primary Pulmonary Hypertension(4)
          Small Cell Lung Carcinoma(1)
          Lung Neoplasms(1)
          Emphysema(1)
          Lung Diseases, Interstitial(1)
          Pulmonary Fibrosis(1)
          Lung Diseases(1)

Phase 3:Aborted:
          Hypertension(11)
          Hypertension, Pulmonary(8)
          Lung Diseases(4)
          Familial Primary Pulmonary Hypertension(4)
          Pulmonary Disease, Chronic Obstructive(2)
          Lung Diseases, Obstructive(2)
          Ischemia(2)
          Peripheral Arterial Disease(2)
          Peripheral Vascular Diseases(2)
          Vascular Diseases(2)
          Respiratory Tract Diseases(1)
          (skip...)

Phase 4:Ongoing:
          Ventricular Remodeling(1)
          Hypertension(1)
          Familial Primary Pulmonary Hypertension(1)
          Pulmonary Arterial Hypertension(1)

Phase 4:Finished:
          Hypertension(6)
          Familial Primary Pulmonary Hypertension(5)
          Pulmonary Arterial Hypertension(2)
          Hypertension, Pulmonary(2)

Phase 4:Aborted:
          Hypertension(6)
          Familial Primary Pulmonary Hypertension(4)
          Hypertension, Pulmonary(2)
          Pulmonary Arterial Hypertension(2)

ALL - - 6 1 2 - 2 2
2024 - - - - - - - -
2023 - - 1 - - - - -
2022 - - 1 1 - - - 1
PTCT
(PTC Therapeutics Inc.)
pharmaceuticals
Insider Trading
Institutional Holding
Phase 1:Finished:
          Muscular Dystrophy, Duchenne(2)
          Muscular Dystrophies(2)
          Leiomyosarcoma(1)
          Renal Insufficiency(1)
          Liver Diseases(1)
          Breast Neoplasms(1)

Phase 1:Aborted:
          Leukemia, Myeloid, Acute(1)
          Leukemia, Myeloid(1)
          Leukemia(1)
          Neoplasms(1)

Phase 2:Ongoing:
          Huntington Disease(2)
          Friedreich Ataxia(1)
          Cerebellar Ataxia(1)
          Ataxia(1)
          Sclerosis(1)
          Amyotrophic Lateral Sclerosis(1)
          Motor Neuron Disease(1)

Phase 2:Finished:
          Muscular Dystrophy, Duchenne(6)
          Muscular Dystrophies(6)
          Fibrosis(4)
          Cystic Fibrosis(4)
          Syndrome(2)
          Leigh Disease(2)
          Gastroparesis(1)
          Phenylketonurias(1)
          Aniridia(1)
          Sclerosis(1)
          Amyotrophic Lateral Sclerosis(1)
          (skip...)

Phase 2:Aborted:
          Muscular Dystrophy, Duchenne(3)
          Muscular Dystrophies(3)
          Aniridia(1)
          Amino Acid Metabolism, Inborn Errors(1)
          Metabolism, Inborn Errors(1)
          Hemophilia B(1)
          Hemophilia A(1)
          Neurofibromatosis 2(1)
          Neurofibroma(1)
          Neurofibromatosis 1(1)
          Neurofibromatoses(1)
          (skip...)

Phase 3:Ongoing:
          Phenylketonurias(2)
          Friedreich Ataxia(1)
          Cerebellar Ataxia(1)
          Ataxia(1)
          Leiomyosarcoma(1)
          Mitochondrial Diseases(1)
          Muscular Dystrophy, Duchenne(1)
          Muscular Dystrophies(1)

Phase 3:Finished:
          Muscular Dystrophy, Duchenne(3)
          Muscular Dystrophies(3)
          Fibrosis(3)
          Cystic Fibrosis(3)
          Nervous System Diseases(2)
          Muscular Disorders, Atrophic(2)
          Muscular Diseases(2)
          Musculoskeletal Diseases(2)
          Phenylketonurias(1)
          Friedreich Ataxia(1)
          Cerebellar Ataxia(1)
          (skip...)

Phase 3:Aborted:
          Muscular Dystrophies(3)
          Fibrosis(2)
          Cystic Fibrosis(2)
          Muscular Dystrophy, Duchenne(2)
          Coronavirus Infections(1)
          COVID-19(1)
          Muscular Dystrophies, Limb-Girdle(1)
          Nervous System Diseases(1)
          Muscular Disorders, Atrophic(1)
          Muscular Diseases(1)
          Musculoskeletal Diseases(1)
          (skip...)

ALL - 5 6 - 2 - - -
2024 - 1 1 - - - - -
2023 - - - - - - - -
2022 - 3 3 - - - - -
NRC
(National Research Corporation)
commercial physical/biological research or service
Insider Trading
Institutional Holding
Phase 1:Ongoing:
          COVID-19(1)

Phase 1:Finished:
          COVID-19(1)

Phase 2:Ongoing:
          Lymphoma(2)
          Hodgkin Disease(1)
          Leukemia, Myelogenous, Chronic, BCR-ABL Positive(1)
          Leukemia, Myeloid(1)
          Leukemia(1)
          Respiratory Distress Syndrome, Newborn(1)
          Respiratory Distress Syndrome, Adult(1)
          Coronavirus Infections(1)
          COVID-19(1)
          Communicable Diseases(1)
          Infections(1)
          (skip...)

Phase 2:Finished:
          COVID-19(1)
          Overweight(1)
          Colorectal Neoplasms(1)
          Cardiovascular Diseases(1)

Phase 2:Abnormal:
          Vomiting(2)
          Nausea(2)
          Recurrence(1)
          Graft vs Host Disease(1)
          (1)
          Anemia, Aplastic(1)
          Neutropenia(1)
          Shock, Septic(1)
          Postoperative Nausea and Vomiting(1)

Phase 3:Ongoing:
          Lymphoma(3)
          Constriction, Pathologic(1)
          Malocclusion(1)
          Graft vs Host Disease(1)
          Hematologic Neoplasms(1)
          Lymphoma, Large B-Cell, Diffuse(1)
          Lymphoma, Follicular(1)

Phase 3:Finished:
          COVID-19(1)
          Postoperative Nausea and Vomiting(1)
          Vomiting(1)
          Nausea(1)
          Schizophrenia(1)

Phase 3:Abnormal:
          Multiple Myeloma(1)

Phase 4:Finished:
          Constriction, Pathologic(1)
          Tracheal Stenosis(1)

Phase 4:Abnormal:
          Leukemia, Myeloid, Acute(1)
          Leukemia, Myeloid(1)
          Leukemia(1)

Phase Not Applicable:Ongoing:
          Precursor Cell Lymphoblastic Leukemia-Lymphoma(3)
          Dental Caries(2)
          Ischemia(2)
          Myocardial Ischemia(2)
          Cardiovascular Diseases(2)
          Atrial Fibrillation(2)
          Leukemia, Lymphoid(2)
          Leukemia(2)
          Glucose Intolerance(1)
          Prediabetic State(1)
          Overweight(1)
          (skip...)

Phase Not Applicable:Finished:
          Musculoskeletal Diseases(10)
          Metabolic Syndrome(3)
          Syndrome(3)
          Anemia, Iron-Deficiency(3)
          Anemia(3)
          Musculoskeletal Pain(3)
          Dental Caries(2)
          Diabetes Mellitus, Type 2(2)
          Diabetes Mellitus(2)
          Cardiovascular Diseases(2)
          Shoulder Pain(2)
          (skip...)

Phase Not Applicable:Aborted:
          Wounds and Injuries(1)
          Female Athlete Triad Syndrome(1)
          Musculoskeletal Diseases(1)

ALL 1 5 6 - - - - -
2024 - 1 - - - - - -
2023 - - 1 - - - - -
2022 - 2 1 - - - - -




(Continued) Drugs Marketing/Approval Status in USA, Europe, Canada

Symbol SMA (50w/20w/10w/5w / 50d/20d/10d/5d) Year United States Europe Canada
Human Animal Bioproduct Human Animal Human Animal
Marketed Tentative Approval Marketed Tentative Approval Marketed Tentative Approval Marketed Positive Marketed Positive Marketed Approved Marketed Approved
AZN
(AstraZeneca PLC)
pharmaceuticals
Insider Trading
Institutional Holding
ALL 43 - - - - - 32 1 - - 42 4 - -
2024 - - - - - - - - - - - 1 - -
2023 4 - - - - - 1 1 - - 2 1 - -
2022 3 - - - - - 5 - - - 1 - - -
MRK
(Merck & Company Inc.)
pharmaceuticals
Insider Trading
Institutional Holding
ALL 34 1 - - 18 - 47 2 - - 37 1 - -
2024 - - - - - - - - - - - - - -
2023 - - - - - - 1 2 - - - - - -
2022 - - - - - - 1 - - - 1 1 - -
NVS
(Novartis AG)
pharmaceuticals
Insider Trading
Institutional Holding